Protein Alignment Axn and RGS6

DIOPT Version :10

• Sequence 1: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: XP_024305527.1
• Gene: RGS6 / 9628
• HGNCID: 10002
• Length: 684
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 69/294 - (23%)
• Similarity: 112/294 - (38%)
• Gaps: 45/294 - (15%)

  Fly    24 PGEESRVKKMTEGVA--DTSKNSSPS---YLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHL 83
            |.|.|. ..:::.||  |...:..||   ...|..:.:.:|:|:.|.:.|.:::|.|..:.|  |
Human   302 PAEPSN-PWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSEN--L 363

  Fly    84 NFYFACEGLKQQTDPEKIKQIIGAIYRFLRKSQLSI----SDDLRAQIKAIKTNPEIPLSPHIFD 144
            .|:.|.:.||:|...:..|::......||.....|.    |.......:.:|..     ..:.|:
Human   364 RFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDG-----GRYTFE 423

  Fly   145 PMQRHVEVTIRDNIYPTFLCSEMY---ILYIQQMSAQQERCTS-SGATGSGSAGSSGSGGSSLAG 205
            ..|.|:...::.:.|..||.|..|   :|..::..::|.|.|| ...|.|.:..::...|:....
Human   424 DAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKPESEQGRRTSLEKFTRSVNVQNTRPAGAWSIF 488

  Fly   206 ACALP-------PTTASGKQQLPQLVPPGAFINLPVSSVSG--PPAG------TCSASGSVYGP- 254
            ..|||       |.:..|..:...|..|.....|....|:|  .|.|      |...:|...||
Human   489 MAALPMAVWLRTPRSCHGLSESRLLGLPSLHDGLREGKVAGGQAPHGPDAVLLTVPTAGPGPGPA 553

  Fly   255 --------STSASSSGSISATDTLPRSSTLPTLH 280
                    ||||..........|:.....:||||
Human   554 DPTGRRRRSTSADRVSLRGDLVTVKEKDCIPTLH 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:470619	27/121 (22%)
		Axin_b-cat_bind	495..530	CDD:462616
		DIX	665..741	CDD:459936
RGS6	XP_024305527.1	DEP_RGS7-like	31..119	CDD:239897
		RGS_DHEX	116..217	CDD:375589
		GGL	258..319	CDD:128520	5/17 (29%)
		RGS_RGS6	328..452	CDD:188691	28/130 (22%)