DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and RGS9

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_003826.2	Gene:	RGS9 / 8787	HGNCID:	10004	Length:	674	Species:	Homo sapiens

Alignment Length:	282	Identity:	60/282 - (21%)
Similarity:	105/282 - (37%)	Gaps:	71/282 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQTDPEKIKQIIGAIYR-FL-- 112
            ||...:.|:.|..|.:.|:.::::|....|  |.|:.|||.|| ..|..|:|:....||: ||
Human   299 WAFNFSELIRDPKGRQSFQYFLKKEFSGEN--LGFWEACEDLK-YGDQSKVKEKAEEIYKLFLAP 360

  Fly   113 -RKSQLSI-SDDLRAQIKAIKTNPEIPLSPH--IFDPMQRHVEVTIRDNIYPTFLCSEMY----- 168
             .:..::| ...:...:|.:|       .||  :.|..|.|:.:.::.:.|..:|.|.:|
Human   361 GARRWINIDGKTMDITVKGLK-------HPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKDMLA 418

  Fly   169 ------------------------------ILYIQQMSAQQERCTSSGATGSGSAGSSGSGGSSL 203
                                          :..:::.:..:|...:...|..|...:.....:..
Human   419 KAIEPQETTKKSSTLPFMRRHLRSSPSPVILRQLEEEAKAREAANTVDITQPGQHMAPSPHLTVY 483

  Fly   204 AGACALP----PTTASGKQQLPQLVPPGAFINLPVSSVSGPP-------------AGTCSASGSV 251
            .|.|..|    |.::|.:........|..||..|.:::...|             .|.||.|.:.
Human   484 TGTCMPPSPSSPFSSSCRSPRKPFASPSRFIRRPSTTICPSPIRVALESSSGLEQKGECSGSMAP 548

  Fly   252 YGPSTSASSSGSISATDTLPRS 273
            .|||.:.||..|:..  :.|||
Human   549 RGPSVTESSEASLDT--SWPRS 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	32/156 (21%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
RGS9	NP_003826.2	DEP_RGS7-like	22..109	CDD:239897
		GGL	224..283	CDD:128520
		RGS_RGS9	295..415	CDD:188693	34/125 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..573		13/38 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810