DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and RGS11

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_011521021.1	Gene:	RGS11 / 8786	HGNCID:	9993	Length:	499	Species:	Homo sapiens

Alignment Length:	132	Identity:	36/132 - (27%)
Similarity:	63/132 - (47%)	Gaps:	14/132 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SSPSYL---NWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQTDPEKIKQII 105
            ::|:.|   .|..:...||||..|...|..::.:|....|  |:|:.|||.|:.....: :..::
Human   322 AAPTKLRVERWGFSFRELLEDPVGRAHFMDFLGKEFSGEN--LSFWEACEELRYGAQAQ-VPTLV 383

  Fly   106 GAIY-RFLRKSQLS-ISDDLRAQIKAIKTNPEIPLSPH--IFDPMQRHVEVTIRDNIYPTFLCSE 166
            .|:| :||...... ::.|.|...:.:    |....||  :.|..|.|:.:.::.:.||.||.|:
Human   384 DAVYEQFLAPGAAHWVNIDSRTMEQTL----EGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSD 444

  Fly   167 MY 168
            ||
Human   445 MY 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	33/118 (28%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
RGS11	XP_011521021.1	DEP_RGS7-like	24..106	CDD:239897
		GGL	255..316	CDD:128520
		RGS_RGS11	327..452	CDD:188694	35/127 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810