DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and RGS20

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_733466.1	Gene:	RGS20 / 8601	HGNCID:	14600	Length:	388	Species:	Homo sapiens

Alignment Length:	175	Identity:	43/175 - (24%)
Similarity:	76/175 - (43%)	Gaps:	21/175 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IRKHDDNECSGPRPPVPGEESRVKKMT--EGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKK 70
            :|..:|.     ||.:...|.|....|  |..|.|.:..:.    ||::.:.|:....|...|::
Human   223 VRNQEDQ-----RPTIASHELRADLPTWEESPAPTLEEVNA----WAQSFDKLMVTPAGRNAFRE 278

  Fly    71 YVEEEAPAYNDHLNFYFACEGLKQQTDPEKIKQIIGAIYR----FLRKSQLSISDDLRAQIKAIK 131
            ::..|..  .:::.|:.|||.||::.:...|::....||.    .|...::|:...:|..|....
Human   279 FLRTEFS--EENMLFWMACEELKKEANKNIIEEKARIIYEDYISILSPKEVSLDSRVREVINRNM 341

  Fly   132 TNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMS 176
            ..|    |.||||..|..:...:..:.||.|:.|.:|...:|.:|
Human   342 VEP----SQHIFDDAQLQIYTLMHRDSYPRFMNSAVYKDLLQSLS 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	29/118 (25%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
RGS20	NP_733466.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..199
RGS20	NP_733466.1	RGS_RGS20	221..376	CDD:188700	41/167 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810