DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and Rgs2

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_445905.1	Gene:	Rgs2 / 84583	RGDID:	621665	Length:	211	Species:	Rattus norvegicus

Alignment Length:	174	Identity:	45/174 - (25%)
Similarity:	74/174 - (42%)	Gaps:	17/174 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGPRPPVPGEESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYND 81
            |.|..|..|::|:.:...       |.|....|.||...:.||..:.|:..|:.:::.|  ...:
  Rat    53 STPGKPKTGKKSKQQTFI-------KPSPEEALLWAEAFDELLASKYGLAAFRAFLKSE--FCEE 108

  Fly    82 HLNFYFACEGLKQQTDPEKIKQIIGAIYR-FLRK-SQLSISDDLRAQIKAIKTNPEIPLSPHIFD 144
            ::.|:.|||..|:...|:|:......||. |:.| :...|:.|.  |.|.:........:...|.
  Rat   109 NIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDF--QTKTLIAQNIQEATSGCFT 171

  Fly   145 PMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTSSGAT 188
            ..|:.|...:.:|.||.||.||.|    |.:..:.:..|...||
  Rat   172 TAQKRVYSLMENNSYPRFLESEFY----QDLCKKPQITTEPHAT 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	31/116 (27%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
Rgs2	NP_445905.1	Necessary for membrane association. /evidence=ECO:0000250\|UniProtKB:P41220	32..66		5/12 (42%)
		Necessary to inhibit protein synthesis. /evidence=ECO:0000250\|UniProtKB:P41220	79..116		8/38 (21%)
		RGS_RGS2	84..197	CDD:188664	31/120 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900