DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axn and AXIN2

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_004646.3	Gene:	AXIN2 / 8313	HGNCID:	904	Length:	843	Species:	Homo sapiens

Alignment Length:	949	Identity:	213/949 - (22%)
Similarity:	334/949 - (35%)	Gaps:	326/949 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSGIRKHDDNECSGPRPPVPGEE----------------------SRVKKMTEGVADTSKNSSPS 47
            ||...:.|     .|||||||||                      |..::..:|:.:....:||.
Human    13 PSSSFRED-----APRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEPEGRASPD 72

  Fly    48 --YLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQT-DPEKIKQIIGAIY 109
              ...|.::|:.||.|:||..||:.::|.|...  |.|:|:|||.|.:|.. ...|..::..|||
Human    73 SPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCV--DTLDFWFACNGFRQMNLKDTKTLRVAKAIY 135

  Fly   110 RFLRKSQLSISDDLRAQIK-----AIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYI 169
            :...::...:|..|:...|     .||..   .:...:||..|..::..:.:|.|..||.|::|:
Human   136 KRYIENNSIVSKQLKPATKTYIRDGIKKQ---QIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYL 197

  Fly   170 LYIQQMSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPV 234
            .|::           ||  |..:|..|..|..||...|...||....::
Human   198 EYVR-----------SG--GENTAYMSNGGLGSLKVVCGYLPTLNEEEE---------------- 233

  Fly   235 SSVSGPPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEG 299
                    .||:.......|:....||.::.||.::..:.|
Human   234 --------WTCADFKCKLSPTVVGLSSKTLRATASVRSTET------------------------ 266

  Fly   300 GGSLGSGSVGAGARAPDYPIRLTRDLLIATQKRRLEIRPPGAH---GYVYNPSTTNTSYVPNSRV 361
                    |.:|.|               :.||...:.|  .|   |||:.|:|        |..
Human   267 --------VDSGYR---------------SFKRSDPVNP--YHIGSGYVFAPAT--------SAN 298

  Fly   362 DSERASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSAMANKETNTFQVIPRTQRL 426
            |||   :||...|| |:||::..|:||.|..:........:.:.:|..||.:. :....|||.||
Human   299 DSE---ISSDALTD-DSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQV-SLPHFPRTHRL 358

  Fly   427 HSNEHRPLKEEELVSLLIPKLE----EVKRKRDLEERAR-----ERNPGAALLTNERSSASDRAF 482
             ..|..|::.....:.||.:||    |::.:..||||.:     |...|:.|..|.|..|..: .
Human   359 -PKEMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ-H 421

  Fly   483 AEAIREKFALDEDNDQDILDQHVSRVWKDQTPH-RSPGTMSPCPPIPSRRRTATH---------- 536
            ..::....:.:|| .|.|||.|:|||.|  ||. :|||.....|    |.|:..|
Human   422 PLSLLPSGSYEED-PQTILDDHLSRVLK--TPGCQSPGVGRYSP----RSRSPDHHHHHHSQYHS 479

  Fly   537 --------DSGMVSDGAMSLSG--------------HSMKHSKSMPD------------------ 561
                    .....|.||..|.|              |...|..::|.
Human   480 LLPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCP 544

  Fly   562 -------HSSCS--RKLTNKWPS----------------MNTDSGIS------------------ 583
                   :|.|.  .|.....||                ..|:.|::
Human   545 GGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAPGGAGALQLP 609

  Fly   584 -------------MFSADTVTKYKDASSRS-------GSSTASKLEEAKR--------------- 613
                         |..::..:|.|..|::|       .|:.:|..|.|.|
Human   610 REEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRTTP 674

  Fly   614 ---------------------RLEDEPRRSRRYAQPPMQH---LSQQPLASFSSSSSGGS--ISL 652
                                 :||:..||....::||.|.   .|||...:.|::...|:  .|.
Human   675 RAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSN 739

  Fly   653 P------HQPPPLPA-----KPPETIVVFSFCEEPVPYRIKIPGTQPTLRQFKDYLPRRGHFRFF 706
            |      |:.|...|     :..|.:|.:.||.|.:|||..:.....||..||:.|.::|::|::
Human   740 PSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYY 804

  Fly   707 FKTHCEDPDSPVIQEEIVNDSDILPLFGDKAMGLVKPSD 745
            ||...::.....:.|||..|..:||::..:.:|.|:..|
Human   805 FKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVERID 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	36/120 (30%)
		Axin_b-cat_bind	494..543	CDD:285982	20/67 (30%)
		DIX	665..739	CDD:279160	23/73 (32%)
AXIN2	NP_004646.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		16/66 (24%)
		AXIN1_TNKS_BD	10..73	CDD:293252	16/64 (25%)
		Tankyrase-binding motif	21..30		7/8 (88%)
		RGS_Axin	82..198	CDD:188662	36/120 (30%)
		Interaction with GSK3B. /evidence=ECO:0000250	327..413		22/87 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..435		8/40 (20%)
		Interaction with beta-catenin. /evidence=ECO:0000250	413..476		22/70 (31%)
		Axin_b-cat_bind	432..467	CDD:285982	19/41 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..494		10/52 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..674		14/112 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..748		7/29 (24%)
		DAX	761..843	CDD:197474	25/81 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9652
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4120
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50119
OrthoDB	1	1.010	-	-		D1481971at2759
OrthoFinder	1	1.000	-	-		FOG0003472
OrthoInspector	1	1.000	-	-		otm41491
orthoMCL	1	0.900	-	-		OOG6_105312
Panther	1	1.100	-	-	LDO	PTHR46102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4975
SonicParanoid	1	1.000	-	-		X2363
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870