DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Axn and AXIN1

DIOPT Version :9

Sequence 1:NP_733336.1 Gene:Axn / 43565 FlyBaseID:FBgn0026597 Length:745 Species:Drosophila melanogaster
Sequence 2:XP_011520984.1 Gene:AXIN1 / 8312 HGNCID:903 Length:916 Species:Homo sapiens


Alignment Length:987 Identity:226/987 - (22%)
Similarity:356/987 - (36%) Gaps:400/987 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 PRPPVPGEESRVKKMT-----------EGVA---------------------DTSKNSSPSYLNW 51
            |||||||||..:....           :||.                     :.|.:.:|.||.|
Human    70 PRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKW 134

  Fly    52 ARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQ----QTDPEKIKQIIGAIYR-F 111
            |.:|:.||:|:||:.||:.::::|..|  |.|:|:|||.|.::    .::.||..::..|||| :
Human   135 AESLHSLLDDQDGISLFRTFLKQEGCA--DLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKY 197

  Fly   112 LRKSQLSISDDLRAQIKAIKTNPEIP--LSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQ 174
            :..:...:|...:...|:......:.  :.|.:||..|..::.|:.:|.||:||.|::|:.|.:.
Human   198 ILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRT 262

  Fly   175 MSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSG 239
            .|...:.|:..         |||||               :||                  .:||
Human   263 GSESPKVCSDQ---------SSGSG---------------TGK------------------GISG 285

  Fly   240 PPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLG 304
                                               .||||:||.... ||.    .|.|..|.  
Human   286 -----------------------------------YLPTLNEDEEWK-CDQ----DMDEDDGR-- 308

  Fly   305 SGSVGAGARAPDYPIRLTRDLLIATQKRRLEIRPPGAHGYVY---------NPSTTNTSYV---P 357
                   ..||  |.||.:.||:.|...|:......:.|..:         ||...|..|.   .
Human   309 -------DAAP--PGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPA 364

  Fly   358 NSRVDSERASVSSGGRTDSDTMSISSCSMDG-RPY-IQRRHSSTESKAIRQSAMAN--------- 411
            .|..|||:.|:||    |:||:|::..|:|| .|| |:::|    .:.:::|...|         
Human   365 TSANDSEQQSLSS----DADTLSLTDSSVDGIPPYRIRKQH----RREMQESVQVNGRVPLPHIP 421

  Fly   412 --KETNTFQVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNER 474
              ....|::| |:..|:   |.:...||     ||.:||.|:|.|:.||:..||.....:  .|.
Human   422 SCPSQRTYRV-PKEVRV---EPQKFAEE-----LIHRLEAVQRTREAEEKLEERLKRVRM--EEE 475

  Fly   475 SSASDRAF--------------------------AEAIREKFALDEDNDQDILDQHVSRVWKDQT 513
            ....|.:.                          ...:|:   ..|:|.:.|||:||.||.    
Human   476 GEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRD---AHEENPESILDEHVQRVL---- 533

  Fly   514 PHRSPGTMSPCPPIPSRRRTATHDSGMVSDGAMSLSGHSMKHSKSMPD----------------- 561
              |:||..||.|...|      .|||.|:...::|.|.:..|.|.:|.                 
Human   534 --RTPGRQSPGPGHRS------PDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLHHHRHVH 590

  Fly   562 ---HSSCSR-------KLTNK------W-------------------PSMNTDSGIS-------- 583
               |.|.:|       :.|.:      |                   .:.|...|::        
Human   591 HHVHHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVA 655

  Fly   584 -MFSADTVTKYKDASS------------------------------RSGSSTA------------ 605
             ..:|......|.||:                              |:|..::            
Human   656 CKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHENSR 720

  Fly   606 --------------------------------------SKLEEAKRRLEDEPRRS------RRYA 626
                                                  ::||||:||||:|.:|:      :||.
Human   721 PLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEEKRASRAPSKQRYV 785

  Fly   627 Q--------------PPMQH----LSQQPLASFSSSS----SGGSISLPHQPPPLPAKPPETIVV 669
            |              .|:.|    :|...|:...:.|    .|||           |:|.::|||
Human   786 QEVMRRGRACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGGS-----------AQPCDSIVV 839

  Fly   670 -FSFCEEPVPYRIKIPGTQPTLRQFKDYLPRRGHFRFFFKTHCEDPDSPVIQEEIVNDSDILPLF 733
             :.||.||:|||..:.|...||.|||:.|.::|.:|::||...::.|..|:.||:..|..:||:|
Human   840 AYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVF 904

  Fly   734 GDKAMGLVKPSD 745
            .:|.:|.|:..|
Human   905 EEKIIGKVEKVD 916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AxnNP_733336.1 RGS 55..170 CDD:295367 37/121 (31%)
Axin_b-cat_bind 494..543 CDD:285982 20/48 (42%)
DIX 665..739 CDD:279160 30/74 (41%)
AXIN1XP_011520984.1 Axin_TNKS_binding 60..129 CDD:211424 12/58 (21%)
RGS_Axin 138..258 CDD:188662 37/121 (31%)
Axin_b-cat_bind 518..574 CDD:285982 25/67 (37%)
DIX 836..911 CDD:279160 30/74 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 69 1.000 Domainoid score I9652
eggNOG 1 0.900 - - E1_KOG3589
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 170 1.000 Inparanoid score I4120
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50119
OrthoDB 1 1.010 - - D1481971at2759
OrthoFinder 1 1.000 - - FOG0003472
OrthoInspector 1 1.000 - - otm41491
orthoMCL 1 0.900 - - OOG6_105312
Panther 1 1.100 - - O PTHR46102
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4975
SonicParanoid 1 1.000 - - X2363
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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