DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and rgs9b

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_957124.2	Gene:	rgs9b / 793087	ZFINID:	ZDB-GENE-040426-1708	Length:	661	Species:	Danio rerio

Alignment Length:	347	Identity:	75/347 - (21%)
Similarity:	121/347 - (34%)	Gaps:	105/347 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VPGEESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYF 87
            :|..|:..|...|              .|..:...||.|:.|...|:.::::|....|  |.|:.
Zfish   285 MPNVETPTKMRVE--------------RWTFSFGELLTDQRGRADFRLFLKKEFSGEN--LAFWE 333

  Fly    88 ACEGLK---QQTDPEKIKQIIGAIYR-FL-RKSQLSISDD---LRAQIKAIKTNPEIPLSPH--I 142
            |||.||   .:|..||.:|    ||: || |.:...|:.|   :...:|.:.       .||  :
Zfish   334 ACEDLKWGAAETMKEKAQQ----IYKTFLARGAPRWINIDGKTMEITVKGLG-------HPHRYV 387

  Fly   143 FDPMQRHVEVTIRDNIYPTFLCSEMY---------------------------------ILYIQQ 174
            .|..|.|:.:.::.:.|..:|.|.::                                 |:..||
Zfish   388 LDAAQTHIYMLMKKDSYGRYLKSPVFKETQKKAIAPEAHRFSEAQLEQNAKRRRPSLSPIILRQQ 452

  Fly   175 MSAQQERCTSSGATGSGSAGSSGSGGSSLA---GACALPPTTASGKQQLPQLVPPGAFINLPVS- 235
            ...|:.:..:||...........:....||   |.|....||:.|...||.    .|....|:|
Zfish   453 EEEQKAKLAASGPVDITQLCRFTAPVPHLAVYTGFCEAQSTTSPGLMTLPN----SAACPSPISV 513

  Fly   236 SVSGPPAGTCSASGSVYGPSTS-------------------ASSSGSISATDTLPRSSTLPTLHE 281
            ::...||......|: .|||:|                   ..|..::|.:..|.|....|::.
Zfish   514 AIDSTPASERRFDGN-GGPSSSHFPSIAEAPVSEEENQPPAPKSRMALSLSRLLRRGCNAPSVF- 576

  Fly   282 DSVLSLCDDFEKVQMQEGGGSL 303
             :.||     .|..:..|||.:
Zfish   577 -ASLS-----PKCGVASGGGKV 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	34/157 (22%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
rgs9b	NP_957124.2	DEP_RGS7-like	26..112	CDD:239897
		GGL	223..283	CDD:128520
		RGS_RGS9	295..415	CDD:188693	36/146 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900