Protein Alignment Axn and Axin1

DIOPT Version :9

• Sequence 1: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_077381.1
• Gene: Axin1 / 79257
• RGDID: 620859
• Length: 832
• Species: Rattus norvegicus
• Alignment Length: 943
• Identity: 226/943 - (23%)
• Similarity: 350/943 - (37%)
• Gaps: 352/943 - (37%)

  Fly    19 PRPPVPGEE--------------------SRVKKMTEGVA------------DTSKNSSPSYLNW 51
            |||||||||                    :.:|..|....            :.|.:.:|.||.|
  Rat    26 PRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPYLRW 90

  Fly    52 ARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQ----QTDPEKIKQIIGAIYR-F 111
            |.:|:.||:|:||:.||:.::::|..|  |.|:|:|||.|.::    .::.||..::..|||| :
  Rat    91 AESLHSLLDDQDGISLFRTFLKQEGCA--DLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKY 153

  Fly   112 LRKSQLSISDDLRAQIKAIKTN--PEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQ 174
            :..|...:|...:...|:...:  .:..:.|.:||..|..::.|:.:|.||:||.|::|:.|.:.
  Rat   154 ILDSNGIVSRQTKPATKSFIKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRT 218

  Fly   175 MSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSG 239
            .|...:.|:..         |||||             |..|
  Rat   219 GSESPKVCSDQ---------SSGSG-------------TGKG----------------------- 238

  Fly   240 PPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLG 304
                                            .|..||||:||.... ||       |:.....|
  Rat   239 --------------------------------MSGYLPTLNEDEEWK-CD-------QDADEDDG 263

  Fly   305 SGSVGAGARAPDYPIRLTRDLLIATQKRRL----------EIRPPGAHGYVYNPSTTNTSYV--- 356
            ..||.        |.|||:.||:.|...|.          |:| .|:.....||...|:.|.
  Rat   264 RDSVP--------PSRLTQKLLLETAAPRAPSSRRYNEGRELR-YGSWREPVNPYYVNSGYALAP 319

  Fly   357 PNSRVDSERASVSSGGRTDSDTMSISSCSMDG-RPY-IQRRHSSTESKAIRQSAMANKETNTFQV 419
            ..|..|||:.|:||    |:||:|::..|:|| .|| |:::|    .:.:::|...|... ....
  Rat   320 ATSANDSEQQSLSS----DADTLSLTDSSVDGIPPYRIRKQH----RREMQESVQVNGRV-PLPH 375

  Fly   420 IPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARER--------------NPGAALL 470
            ||||.|: ..|.| ::.::....||.:||.|:|.|:.||:..||              .|...:.
  Rat   376 IPRTYRM-PKEIR-VEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGEMPSGPMA 438

  Fly   471 TNERSSAS----------DRAFAEAIREKFALDEDNDQDILDQHVSRVWKD---QTP---HRSP- 518
            :::..|..          |.. ...:|:   ..|:|.:.|||:||.||.:.   |:|   ||||
  Rat   439 SHKLPSVPAWHHFPPRYVDMG-CSGLRD---AHEENPESILDEHVQRVMRTPGCQSPGPGHRSPD 499

  Fly   519 -----------GTMS----PCPPI----------------------------------------- 527
                       ||.|    ..|.:
  Rat   500 SGHVAKTAVLGGTASGHGKHAPKLGLKLDSAGLHHHRHVHHHVHHNSARPKEQMEAEAARRVQSS 564

  Fly   528 -------------------------------------PSRRRTATHDSG---------------- 539
                                                 ||:|.|...:||
  Rat   565 FSWGPETHGHAKPRSYSESTGTNPSAGDLAFGGKASAPSKRNTKKAESGKNASAEVPSTTEDAEK 629

  Fly   540 ------MVSDGAMSLS-----GHSMKHSKSMPDHSSCSRKLT-------NKWPSMNTDSGIS--- 583
                  .:.:|...:|     ||.....:....|.| ||.|:       :.|.|....:.:.
  Rat   630 NQKIMQWIIEGEKEISRHRKAGHGSSGMRKQQAHES-SRPLSIERPGAVHPWVSAQLRNSVQPSH 693

  Fly   584 MFSADTVTKYKDASSRSGSSTASKLEEAKRRLEDEPRRSRRYAQPPMQHLSQQPLASFSSSSSGG 648
            :|..|.......|     .:..::||||:||||:|.:|:.:.  |..|....|      ..:.||
  Rat   694 LFIQDPTMPPNPA-----PNPLTQLEEARRRLEEEEKRANKL--PSKQRTKSQ------RKAGGG 745

  Fly   649 SISLPHQPPPLPAKPPETIVV-FSFCEEPVPYRIKIPGTQPTLRQFKDYLPRRGHFRFFFKTHCE 712
            |           |.|.::||| :.||.||:|||..:.|...||.|||:.|.::|.:|::||...:
  Rat   746 S-----------APPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSD 799

  Fly   713 DPDSPVIQEEIVNDSDILPLFGDKAMGLVKPSD 745
            :.|..|:.||:..|..|||:|.:|.:|.|:..|
  Rat   800 EFDCGVVFEEVREDEAILPVFEEKIIGKVEKVD 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	38/121 (31%)
		Axin_b-cat_bind	494..543	CDD:285982	25/170 (15%)
		DIX	665..739	CDD:279160	31/74 (42%)
Axin1	NP_077381.1	Axin_TNKS_binding	16..85	CDD:211424	12/58 (21%)
		RGS_Axin	94..214	CDD:188662	38/121 (31%)
		Axin_b-cat_bind	468..521	CDD:285982	18/52 (35%)
		DIX	752..827	CDD:279160	31/74 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9392
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I3959
OMA	1	1.010	-	-		QHG50119
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003472
OrthoInspector	1	1.000	-	-		oto97388
orthoMCL	1	0.900	-	-		OOG6_105312
Panther	1	1.100	-	-	O	PTHR46102
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2363
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970