Protein Alignment Axn and rgs12

DIOPT Version :10

• Sequence 1: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: XP_012811187.1
• Gene: rgs12 / 779463
• XenbaseID: XB-GENE-992792
• Length: 1401
• Species: Xenopus tropicalis
• Alignment Length: 740
• Identity: 160/740 - (21%)
• Similarity: 254/740 - (34%)
• Gaps: 203/740 - (27%)

  Fly    50 NWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQT--DPEKIKQIIGAIY-RF 111
            :||.:...||:|..||..|.:::::|..  .:::.|:.:||...:..  |..::......|: :|
 Frog   701 SWAVSFERLLQDPVGVRYFTEFLKKEFS--EENILFWQSCEYFSRIPIHDKNELSYRAREIFNKF 763

  Fly   112 LRK---------SQLSISDDLRAQIKAIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEM 167
            |..         ||..::||       :...|.    |.:|...|..:...::.:.|..||.|.:
 Frog   764 LSSKATTPVNIDSQAHLADD-------VLNAPH----PDMFKEQQLQIFNLMKFDSYTRFLKSHL 817

  Fly   168 Y----ILYIQQMSAQQERCTSSGATGSGSAGSSGS---------------GGSSLAGACALPPTT 213
            |    :..::..|....:...|..|...|..|..|               .|.||        ..
 Frog   818 YQECMLAEVEGRSLPDPQEVPSSPTSKHSISSERSNISTPKKQQLSKKNRSGRSL--------NE 874

  Fly   214 ASGKQQLPQLVPPGAFINLPVSSVSGP----------PAGTCSASGSVYGPSTSASSSGSISATD 268
            .||.:...:....|||.:...|...|.          .|..||....  |.|....|.||:|::.
 Frog   875 ESGGEDDNERKKKGAFFSWSRSKSIGKSQKKRENGEISAADCSHING--GNSRRRGSQGSVSSSA 937

  Fly   269 TLP-------------RSSTLPTLHE------DSVLSLCDDFEKVQMQEGGGSLG---SG----- 306
            :|.             .||.:.:|||      ...:||.|......:.:.|.|:.   ||
 Frog   938 SLELINCGTNGNALEFESSRVSSLHEKEKVSKQCYISLPDGSSCAMVVKSGLSIKDMLSGLCDKH 1002

  Fly   307 --SVGA------GARAP-----DYPIRLTRDLLIATQKR---RLEIRPPG-AHGYVYNPSTTNT- 353
              ::.|      |...|     |..|..:|||.|  :||   ||::.|.. :.|....|:...|
 Frog  1003 GFNIAAVDLFLIGGNKPLVLSQDSSILESRDLRI--EKRTLFRLDLVPINRSVGLKAKPTKPVTE 1065

  Fly   354 -------SYVPN-----SRVDSERASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQ 406
                   .|..|     :|:..|...:..|       :.||  ::||:..:.....:...|. :|
 Frog  1066 VLRPVVAKYGLNLTELVARLSGEHEPLDLG-------LPIS--NLDGQRVVLEEKENLRGKE-KQ 1120

  Fly   407 SAMANKETNTFQVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERN------- 464
            .|...|.:.|....||:.. .:.|.|||.:...:.|   |.|..|..||    ||..|
 Frog  1121 KAPVLKPSPTVISGPRSPS-SAGEDRPLVKSASIRL---KRENGKGSRD----ARLLNKDEPVVR 1177

  Fly   465 PGAALLTNERSSASDRAFAEAIREKFALDEDN---DQDILDQHVSRVWKD---QTPHRSPGTMSP 523
            ||     ..|....:...|||..|..:..:.|   ||..|.:....|..|   .||..|..: :|
 Frog  1178 PG-----RRRQQKINLDEAEAFFEMISKAQSNRAEDQRGLLRKEDLVLPDFLRLTPSESVSS-TP 1236

  Fly   524 CPPIPSRRRTATHDSGMVSDGAMSLSGHSMKHSKSMPDHSSCSRKLTN----KWPSMNTDSGISM 584
            .....:.:|....|||                     |.::.|.:..|    :.|...||..:..
 Frog  1237 AGSNSNNKRPGRRDSG---------------------DRAAPSSRAMNGTRQETPPKCTDRPLKS 1280

  Fly   585 FSADTVTK--YKDASSRSG----SSTASKLEEAKRRLEDEPRRSRRYAQPPM--------QHLSQ 635
            ...|...|  :..|.||..    ::..|.:...:.|  ::|.:.|.....|:        ::::.
 Frog  1281 GGLDRRDKPDFLQAGSRKPYVPFNAPLSPIPHVQER--NKPGKERHSRDLPLDNIQTIEDENVAD 1343

  Fly   636 QPLASFSSSSSGGSISLPHQPPPLP 660
            ..|.:....||..|..||  |||.|
 Frog  1344 LTLVAEGDISSPNSTLLP--PPPSP 1366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:470619	27/130 (21%)
		Axin_b-cat_bind	495..530	CDD:462616	10/40 (25%)
		DIX	665..741	CDD:459936
rgs12	XP_012811187.1	PDZ_RGS12-like	21..96	CDD:467194
		PTB_RGS12	225..355	CDD:269984
		RGS_RGS12	706..820	CDD:188696	27/126 (21%)
		RGS12_us1	826..948	CDD:465199	26/131 (20%)
		RBD1_RGS12	969..1038	CDD:340656	16/70 (23%)
		RBD2_RGS12	1039..1111	CDD:340658	16/80 (20%)
		RGS12_us2	1113..1184	CDD:435461	23/84 (27%)
		GoLoco	1192..1213	CDD:460481	6/20 (30%)
		RGS12_usC	1240..1388	CDD:465198	30/152 (20%)