DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Axn and Rgs12

DIOPT Version :9

Sequence 1:NP_733336.1 Gene:Axn / 43565 FlyBaseID:FBgn0026597 Length:745 Species:Drosophila melanogaster
Sequence 2:XP_006504183.1 Gene:Rgs12 / 71729 MGIID:1918979 Length:1451 Species:Mus musculus


Alignment Length:729 Identity:155/729 - (21%)
Similarity:250/729 - (34%) Gaps:182/729 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 NWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQ--QTDPEKIKQIIGAIY-RF 111
            :||.:...||:|..||..|..::.:|..  .:::.|:.|||....  ..|.:::......|: :|
Mouse   711 SWAVSFERLLQDPVGVRYFSDFLRKEFS--EENILFWQACECFSHVPAHDKKELSYRAREIFSKF 773

  Fly   112 L-RKSQLSISDDLRAQIKAIKTNPEIPLSPH--IFDPMQRHVEVTIRDNIYPTFLCSEMY----I 169
            | .|:...::.|.:||:.     .:|..:||  :|...|..:...::.:.|..||.|::|    :
Mouse   774 LCSKATTPVNIDSQAQLA-----DDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVL 833

  Fly   170 LYIQQMSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPP-------- 226
            ..::..:....:...|......|..|..|..|:        |...|||.:..:.:..        
Mouse   834 AEVEGRTLPDSQQVPSSPASKHSISSDHSNVST--------PKKLSGKSKSGRSLNEDVGEEDSE 890

  Fly   227 ----GAFINLPVSSVSG---------------PPA--GTC--SASGSVYGPSTSASSSGSISATD 268
                |||.:...|..:|               |.|  |.|  .:.|||       ||:||:..::
Mouse   891 KKRRGAFFSWSRSRSTGRSQKKKDHGDHAHDAPHANGGLCRRESQGSV-------SSAGSLDLSE 948

  Fly   269 TLPRSSTLPTLHEDSVLSLC-----DDFEKVQMQEGGGSLGS---------GSVGA-------GA 312
            ....|:    |.:|.....|     |....|...:.|.|:..         |..||       |.
Mouse   949 ACRTSA----LEKDKAAKHCCVHLPDGTSCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGG 1009

  Fly   313 RAP-----DYPIRLTRDLLIATQKR---RLEIRPPG-AHGYVYNPSTTNTS----YVPNSRVDSE 364
            ..|     |..|..||||.:  :||   ||::.|.. :.|....|:...|.    .|....:|..
Mouse  1010 DKPLVLHQDSSILATRDLRL--EKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLG 1072

  Fly   365 RASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAI--RQSAMANKETNTFQVIPRTQRLH 427
            ...|...|..:...:.....|:||:..|......:..|..  :|.....|:.:.....|| ..|.
Mouse  1073 SLLVRLSGEKEPLDLGAPISSLDGQRVILEERDPSRGKVSTDKQKGAPVKQNSAVNSSPR-NHLA 1136

  Fly   428 SNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNERSSASDRAFAEAIREKFAL 492
            ..|.|.|.:...:.:   :.|..|..||  .|..:|....|.:..::....:...||...|..:.
Mouse  1137 MGEERTLGKSNSIKI---RGENGKSARD--PRLSKREESIAKIGKKKYQKINLDEAEEFFELISK 1196

  Fly   493 DEDNDQDILDQHVSRVWKDQT-PH--RSPG-----TMSPCPPIPSRRRTATHDSGMVSDGAMSLS 549
            .:.|..|  ||......:|.. |.  |.|.     .:|..||:....:.|             ::
Mouse  1197 AQSNRAD--DQRGLLRKEDLVLPEFLRLPAGSSELALSSPPPVKGYSKRA-------------VT 1246

  Fly   550 GHSMKHSKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTKYKDASSRS-GS----------- 602
            ||..:.:....:..|.|       |:.:..|..|..||     |...|:.| ||           
Mouse  1247 GHGQEGAAQTEESYSDS-------PATSPASAQSPCSA-----YSPGSAHSPGSAHSTPGPPGTT 1299

  Fly   603 ---------STASKLEE----AKRRLEDEPRRSRRYAQPPMQHLSQQPLASFSSSSSGGSISLPH 654
                     |..|.::|    |.|||..|....      .:|.:..:.:|..:.... |.||.|:
Mouse  1300 QPGEKPTKPSCVSMVQEGTTQAWRRLSPEMEAG------GIQTVEDEQVADLTLMGE-GDISSPN 1357

  Fly   655 Q----PPPLPAKPP 664
            .    |||.|...|
Mouse  1358 STLLPPPPTPQDTP 1371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AxnNP_733336.1 RGS 55..170 CDD:295367 29/124 (23%)
Axin_b-cat_bind 494..543 CDD:285982 12/56 (21%)
DIX 665..739 CDD:279160 155/729 (21%)
Rgs12XP_006504183.1 PDZ_signaling 19..95 CDD:238492
PTB_RGS12 227..358 CDD:269984
RGS_RGS12 716..830 CDD:188696 29/120 (24%)
RGS12_us1 836..949 CDD:374670 25/127 (20%)
RBD1_RGS12 962..1031 CDD:340656 16/70 (23%)
Ubiquitin_like_fold 1032..1104 CDD:391949 15/71 (21%)
RGS12_us2 1106..1180 CDD:374668 16/79 (20%)
GoLoco 1189..1209 CDD:366965 5/21 (24%)
RGS12_usC 1238..1361 CDD:374669 29/154 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3589
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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