DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and RGS10

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001005339.1	Gene:	RGS10 / 6001	HGNCID:	9992	Length:	181	Species:	Homo sapiens

Alignment Length:	155	Identity:	41/155 - (26%)
Similarity:	79/155 - (50%)	Gaps:	13/155 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGPRPPVPGEESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYND 81
            |..|||....:|      :|.:.:|..|..|...||.:|.:||||.:||:.|::::::|..  .:
Human    10 SRKRPPSDIHDS------DGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFS--EE 66

  Fly    82 HLNFYFACEGLKQQTDPEKIKQIIGAIYRFLRKSQLSISDDLRAQIKAIKTNPEIPLSPH--IFD 144
            ::.|:.|||..|:..|..::::....||.....|:.|...::..|   .:.|.:|...||  :|.
Human    67 NVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQ---SRLNEKILEEPHPLMFQ 128

  Fly   145 PMQRHVEVTIRDNIYPTFLCSEMYI 169
            .:|..:...::.:.|..||.|::::
Human   129 KLQDQIFNLMKYDSYSRFLKSDLFL 153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	30/117 (26%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
RGS10	NP_001005339.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		7/27 (26%)
		RGS_RGS10	42..154	CDD:188695	30/117 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..181
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810