DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and RGS4

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001095915.1	Gene:	RGS4 / 5999	HGNCID:	10000	Length:	302	Species:	Homo sapiens

Alignment Length:	163	Identity:	37/163 - (22%)
Similarity:	67/163 - (41%)	Gaps:	21/163 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WARTLNHLLEDRDGVELFKKYVEEEAPAYN-DHLNFYFACEGLKQQTDPEKI----KQIIGAIYR 110
            ||.:|.:|:....|:..||.:::.|   |: ::::|:.:||..|:...|.|:    |:|......
Human   156 WAESLENLISHECGLAAFKAFLKSE---YSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFIS 217

  Fly   111 FLRKSQLSISDDLRAQIKAIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQM 175
            .....::::....|.:.......|.|.    .||..|:.:...:..:.|..||.|..|:..:...
Human   218 VQATKEVNLDSCTREETSRNMLEPTIT----CFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPS 278

  Fly   176 SAQQERCTSSGATGSGSAGSSGSGGSSLAGACA 208
            |...|:  ..||..|...       :||...||
Human   279 SCGAEK--QKGAKSSADC-------ASLVPQCA 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	26/119 (22%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
RGS4	NP_001095915.1	RGS_RGS4	160..273	CDD:188669	26/119 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810