Protein Alignment Axn and RGS3

DIOPT Version :10

• Sequence 1: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_652759.4
• Gene: RGS3 / 5998
• HGNCID: 9999
• Length: 1094
• Species: Homo sapiens
• Alignment Length: 667
• Identity: 133/667 - (19%)
• Similarity: 199/667 - (29%)
• Gaps: 237/667 - (35%)

  Fly    50 NWARTLNHLLEDRDGVELF-----KKYVEEEAPAYNDHLNFYFACEGLKQQTDPEKIKQIIGAIY 109
            |.||||  ||.:    ||.     .|..|....||:|.|.|       .::.:|.:...:...:|
Human   460 NPARTL--LLSE----ELLLYEGRNKAAEVTLFAYSDLLLF-------TKEDEPGRCDVLRNPLY 511

  Fly   110 RFLRKSQLSISDDLRAQIKAIKTNPE--IPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYI 172
            ....|.|...|:||:..:..:....|  ..|..|..:..:|            ...|....|...
Human   512 LQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKR------------VCWCLSENIAKQ 564

  Fly   173 QQMSA--------------QQERCTSSGATGSGSAGS----SGSGGSSLAGACALPPT--TASGK 217
            ||::|              ::|.....| .|.|:..|    ..|.|..|.....|||.  :.||:
Human   565 QQLAASPPDSKMFETEADEKREMALEEG-KGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQ 628

  Fly   218 QQLPQLVPPGAFINLPVSSVS-GPPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHE 281
            :..|...|    ::...|:.| |.|.|..:.......|......:..:|....||.... |..|:
Human   629 EPAPSQEP----LSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQE-PLPHQ 688

  Fly   282 DSVLSL---------------CDDFEKVQMQEGGGSLGSGSVGAGARAPDYPIRLTRDLLIATQK 331
            |.:|:.               |.|....|:.....:|...::.:|            |||.||..
Human   689 DPLLTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSG------------DLLAATGD 741

  Fly   332 RRLEIRPPGAHGYVYNPSTTNTSYVPNSRVD---SERASVSSGGRTDSDTMSISSCSMDGRPYIQ 393
                  ||.|....:        .:|..|:|   |::|....|            ||.|
Human   742 ------PPAAPRPAF--------VIPEVRLDSTYSQKAGAEQG------------CSGD------ 774

  Fly   394 RRHSSTESKAIRQSAMANKETNTFQVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEE 458
                                                                           ||
Human   775 ---------------------------------------------------------------EE 776

  Fly   459 RARERNPGAALLTNERSSASDRAFAEAIREKFALDEDNDQDILDQH------VSRVWKDQTPHRS 517
            .|.|                    ||.:.|....:||.|:|..|.:      ..|....:|...:
Human   777 DAEE--------------------AEEVEEGEEGEEDEDEDTSDDNYGERSEAKRSSMIETGQGA 821

  Fly   518 PGTMSPCPPIPSRRRTATHDSG----------MVSDGAMSLS-GHSMKHSKSMPDHSSCSRKLTN 571
            .|.:|.......|||  ||..|          ..||..:..| |.....:..||..|:..::|..
Human   822 EGGLSLRVQNSLRRR--THSEGSLLQEPRGPCFASDTTLHCSDGEGAASTWGMPSPSTLKKELGR 884

  Fly   572 KWPSMNTDSGISMF--------SADTVTKYKDASSRSGSSTASKLEEAKRRLEDEPRRSRRYAQP 628
            ...||:   .:|:|        .||||....:||.:..|...:|  :.|.:|....||:.....|
Human   885 NGGSMH---HLSLFFTGHRKMSGADTVGDDDEASRKRKSKNLAK--DMKNKLGIFRRRNESPGAP 944

  Fly   629 PMQHLSQQPLASFSSSS 645
            |... :.:.:.||..:|
Human   945 PAGK-ADKMMKSFKPTS 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:470619	24/121 (20%)
		Axin_b-cat_bind	495..530	CDD:462616	8/40 (20%)
		DIX	665..741	CDD:459936
RGS3	NP_652759.4	C2_RGS-like	35..154	CDD:176067
		PDZ_RGS3-like	194..270	CDD:467195
		PHA03247	<586..748	CDD:223021	41/185 (22%)
		RGS_RGS3	970..1083	CDD:188668