DRSC/TRiP Functional Genomics Resources

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Protein Alignment Axn and RGS2

DIOPT Version :9

Sequence 1:NP_733336.1 Gene:Axn / 43565 FlyBaseID:FBgn0026597 Length:745 Species:Drosophila melanogaster
Sequence 2:NP_002914.1 Gene:RGS2 / 5997 HGNCID:9998 Length:211 Species:Homo sapiens


Alignment Length:174 Identity:43/174 - (24%)
Similarity:73/174 - (41%) Gaps:17/174 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SGPRPPVPGEESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYND 81
            |.|..|..|::|:.:...       |.|......|:...:.||..:.|:..|:.:::.|  ...:
Human    53 STPGKPKTGKKSKQQAFI-------KPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSE--FCEE 108

  Fly    82 HLNFYFACEGLKQQTDPEKIKQIIGAIYR-FLRK-SQLSISDDLRAQIKAIKTNPEIPLSPHIFD 144
            ::.|:.|||..|:...|:|:......||. |:.| :...|:.|.  |.|.:........:...|.
Human   109 NIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDF--QTKTLIAQNIQEATSGCFT 171

  Fly   145 PMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTSSGAT 188
            ..|:.|...:.:|.||.||.||.|    |.:..:.:..|...||
Human   172 TAQKRVYSLMENNSYPRFLESEFY----QDLCKKPQITTEPHAT 211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AxnNP_733336.1 RGS 55..170 CDD:295367 31/116 (27%)
Axin_b-cat_bind 494..543 CDD:285982
DIX 665..739 CDD:279160
RGS2NP_002914.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 14..33
Necessary for membrane association. /evidence=ECO:0000269|PubMed:11278586 32..66 5/12 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..68 5/14 (36%)
Necessary to inhibit protein synthesis. /evidence=ECO:0000269|PubMed:19736320 79..116 7/38 (18%)
RGS_RGS2 84..197 CDD:188664 31/120 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3589
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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