DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axn and axin2

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_571636.1	Gene:	axin2 / 58080	ZFINID:	ZDB-GENE-000403-2	Length:	812	Species:	Danio rerio

Alignment Length:	933	Identity:	215/933 - (23%)
Similarity:	346/933 - (37%)	Gaps:	324/933 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SGIRKHDDNECSGPRPPVPGEE-----------------------------SRVKKMTEGVADTS 41
            |..|:.|      |||||||||                             |..::..:|:.:..
Zfish    11 SSFREDD------PRPPVPGEEGETTCHHPSKLAMMRPKDPVKTIMADLRCSTARRDEDGLGEPE 69

  Fly    42 KNSSPS--YLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQ-QTDPEKIKQ 103
            .::||.  ...|.::|:.||.|:||.:||:.|:|.|...  |.|:|:|||.|.:| .....|..:
Zfish    70 GSASPDSPLARWTKSLHFLLGDQDGAQLFRAYLEREKCV--DTLDFWFACNGFRQMDLKDTKTHR 132

  Fly   104 IIGAIYRFLRKSQLSISDDLRAQIKA-IKTN-PEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSE 166
            :..|||:...::...::..|:...|. |:.| ....:...:||..|..::..:.:|.|..||.|:
Zfish   133 VAKAIYKRYIENNSIVAKQLKPATKTFIRDNIKRQQIDSAMFDQAQMEIQTAMEENAYQMFLTSD 197

  Fly   167 MYILYIQQMSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFIN 231
            :|:.|::           :|.........:|.||..|  .|..
Zfish   198 IYLEYVR-----------TGCENPSHVNPNGLGGLKL--VCGY---------------------- 227

  Fly   232 LPVSSVSGPPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQM 296
                                                        ||||:|:...| |:||:...:
Zfish   228 --------------------------------------------LPTLNEEEEWS-CNDFKAKAL 247

  Fly   297 QEGGGSLGSGSVGAGA---RAPDYPIRLTRDLLIATQK--RRLEIRPPGAHGYVYNPS--TTNTS 354
                    :..||..|   |:|  |:|...    |.:|  |......||      ||:  |:..|
Zfish   248 --------ATVVGLSAKTLRSP--PLRAVE----ALEKGYRSYRRSDPG------NPNRFTSGYS 292

  Fly   355 YVP-NSRVDSERASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSAMANKETN--- 415
            :.| .|..|||   |||...|| |:||::..|:|..|    .:.....|.:::....|...|
Zfish   293 FAPATSANDSE---VSSDALTD-DSMSMTDSSVDAIP----PYKLGSKKQLQREMQRNMRMNGQV 349

  Fly   416 TFQVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRD----LEERARERNPGAALLTNERSS 476
            :....|||:| ...|..|::.....:.||.:||.:||:::    ||||.::      :...|...
Zfish   350 SLPPFPRTRR-PPKEMTPVEPAAFAAQLIARLERLKREQETMSSLEERLQQ------IQEEEERD 407

  Fly   477 ASDRAFAEAIREKFALD----EDNDQDILDQHVSRVWKDQTPH-RSPGTMSPCP--------PIP 528
            .|:.:.:.|......|.    |::.|.|||:|:|||.|  ||. :|||.:...|        |:|
Zfish   408 ESEMSSSSASHSLPLLPPGTCEEDPQAILDEHLSRVLK--TPGCQSPGLLRHSPRSRSPEQRPLP 470

  Fly   529 ----SRRRTATHDSGMVSDGAMSLSGHSMKH---------------------------------- 555
                |.|..::..:|.| .....:|..|.||
Zfish   471 RGGLSTRSQSSSMNGYV-PAKTFISRQSTKHIHHHYIHHHAGPKSKEQIEVEATQRVQCLCHGTS 534

  Fly   556 ---------SKSMP------------DHSSCSRK-------------LTN---KWPSMNTDSGIS 583
                     |:|:.            .|||...|             |.|   :.|:.:||...:
Zfish   535 ECCTAPYIRSRSLGRDQCASPAEVALGHSSTLSKRLCKSGEEVNMEGLENSLLQLPADSTDRSQN 599

  Fly   584 MF----SADTVTKYKDASSRS------------------GSS----------------------- 603
            ::    .:|..||:|..|:::                  |||
Zfish   600 VWQWILESDRQTKHKPHSTQNVKKSHSLEPTRTHTWGGGGSSGHLRAHQPAHPFVQDPAMPPLPP 664

  Fly   604 --TASKLEEAKRRLEDEPRRSR-RYAQPPMQHLSQQPLASFSSSSSGGSISLPHQPPPLPAK--- 662
              |.::||||:||||:..:.|: |::...:|.....|:     ....||.:.|......|.|
Zfish   665 PNTLAQLEEARRRLEEVSKPSKQRHSTSSLQRDKSHPV-----PVQNGSSAFPMDERKDPKKMSG 724

  Fly   663 -----PPETIVVFSFCEEPVPYRIKIPGTQPTLRQFKDYLPRRGHFRFFFKTHCEDPDSPVIQEE 722
                 ..||:|.:.||.|.:|||..:.....||..||:.|.::|::|:|||...::.:...:.||
Zfish   725 CHSSLGSETVVTYFFCGEEIPYRRMMKTHSLTLGHFKEQLRKKGNYRYFFKRASDEFECGAVFEE 789

  Fly   723 IVNDSDILPLFGDKAMGLVKPSD 745
            :.:|..:||::..|.:|.|...|
Zfish   790 VWDDCTVLPMYEGKILGKVDRMD 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	36/117 (31%)
		Axin_b-cat_bind	494..543	CDD:285982	22/61 (36%)
		DIX	665..739	CDD:279160	25/73 (34%)
axin2	NP_571636.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		12/37 (32%)
		AXIN1_TNKS_BD	5..76	CDD:293252	16/70 (23%)
		RGS_Axin	85..201	CDD:188662	36/117 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..326		22/64 (34%)
		Interaction with GSK3B. /evidence=ECO:0000250	329..415		21/92 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..430		8/47 (17%)
		Interaction with beta-catenin. /evidence=ECO:0000250	415..467		18/53 (34%)
		Axin_b-cat_bind	429..464	CDD:285982	16/36 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..484		10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..726		25/121 (21%)
		DIX	732..807	CDD:279160	25/74 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3535
OMA	1	1.010	-	-		QHG50119
OrthoDB	1	1.010	-	-		D1481971at2759
OrthoFinder	1	1.000	-	-		FOG0003472
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105312
Panther	1	1.100	-	-	LDO	PTHR46102
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2363
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.980