DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axn and axin1

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_009297983.1	Gene:	axin1 / 57931	ZFINID:	ZDB-GENE-000403-1	Length:	871	Species:	Danio rerio

Alignment Length:	976	Identity:	228/976 - (23%)
Similarity:	348/976 - (35%)	Gaps:	378/976 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PRPPVPGEESRV---------KKMTEGVADTSKNS-----------------------SPSYLNW 51
            |||||||||..:         .......:|:.||.                       :|.||.|
Zfish    25 PRPPVPGEEGDLVSSDGRQYNHSFYSSKSDSLKNEASIATPRRPDLDLGYEPEGSASPTPPYLKW 89

  Fly    52 ARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQ---TDPEKIKQIIGAIY-RFL 112
            |.:|:.||:|:||:.||:.::::|..|  |.|:|:|||.|.::|   ...||:.::..||| :::
Zfish    90 AESLHSLLDDQDGIHLFRTFLKQEECA--DMLDFWFACSGFRKQEANDGNEKMLKLAKAIYKKYI 152

  Fly   113 RKSQLSISDDLRAQIKAIKTN--PEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQM 175
            ..:...:|..::...|:...:  .::.:.|.:||..|..::..:.:|.||.||.|::|:.|.:
Zfish   153 LDNNGIVSRQIKPATKSFIKDCVMKLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYLEYTR-- 215

  Fly   176 SAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSGP 240
                                  :||.|                  |:|
Zfish   216 ----------------------TGGES------------------PKL----------------- 223

  Fly   241 PAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLGS 305
                       :...:|.|.:|.:     ||  ..|||:.|| |...||. |:.|:.|..
Zfish   224 -----------FSDQSSVSGNGKV-----LP--GYLPTVIED-VEWRCDQ-EEEQIAESD----- 263

  Fly   306 GSVGAGARAPDYPIRLTRDLLIAT---------------QKRRLEIRPPGAHGYVYNPSTTNTSY 355
                     |....|||:.||:.|               :.|....|.|      .||...|:.|
Zfish   264 ---------PTPSNRLTQKLLLETVPQRVANSKRYQDNREYRHASWREP------VNPYYVNSGY 313

  Fly   356 V---PNSRVDSERASVSSGGRTDSDTMSISSCSMDG-RPYIQRRHSSTESKAIRQSAMANKETNT 416
            .   ..|..|||:.|:||    |:||:|::..|:|| .||   |:.....:.|.:||..|... .
Zfish   314 ALAPATSANDSEQQSMSS----DADTLSLTDSSVDGVPPY---RYRKPHRREIHESAKVNGRV-P 370

  Fly   417 FQVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAAL--------LTNE 473
            ...||||.|:..:.|  ::.|:..:.||.:||.|.|:|:.:|:..||.....|        ::..
Zfish   371 LPHIPRTNRIPKDIH--VEPEKFAAELISRLEGVLREREAQEKLEERLKRVRLEEEGDDADISTG 433

  Fly   474 RSSASDR------------AFAEAIREKFAL---DEDNDQDILDQHVSRVWKDQTPH-RSPGTMS 522
            .|.|:.|            .::|.......|   .|:|.:.|||:||.||.|  ||. :||||..
Zfish   434 PSLANHRIPPAVHVQHYGGRYSEMSYNGLQLRDAHEENPESILDEHVQRVMK--TPGCQSPGTGR 496

  Fly   523 PCPPIPSRRRTATHD---SGMVSDGAMSLSG------------------HSMKH----------- 555
            ..|      ::.:.|   :|.:....|.|||                  |..||
Zfish   497 HSP------KSRSPDGLPAGKIPGLMMPLSGGQGKHQARQGPKGEAAHLHHHKHIHHTHYAAAGK 555

  Fly   556 ----------------------------SKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTK 592
                                        |::..|..|..   .|....|...|..|..|...|.|
Zfish   556 PKEQAEAEAARMHGGFAWNTEQHHYGPKSRNYADGMSVG---PNTMDPMGYSSKGSTLSKRPVRK 617

  Fly   593 YKDA---------------------------------------SSRSGSSTA------------- 605
            .:|.                                       .|.||...|
Zfish   618 GEDGRNFEMREPLPADDMERNQKILQWMMEGEKEAGRYKRSPYGSISGPKKAQGHEPARPSSVER 682

  Fly   606 -------------------------------------SKLEEAKRRLEDEPRRS------RRYAQ 627
                                                 ::||||:||||:|.|:|      :||..
Zfish   683 LGAVHPWVTAQLRNNVQPSHPFIQDPTMPPNPAPNPLTQLEEARRRLEEERRKSGTLQAKQRYVM 747

  Fly   628 PPMQH------------LSQQPLASFSSSSSGGSISLPHQPPPLPAKPPETI-VVFSFCEEPVPY 679
            ..:|.            ||..|..|.:..|.....::..|       |.|.| |.:.||.||:||
Zfish   748 EVIQRGRTAVRPALFPALSVVPAVSDTELSDAEHKNMKKQ-------PCENITVAYYFCGEPIPY 805

  Fly   680 RIKIPGTQPTLRQFKDYLPRRGHFRFFFKTHCEDPDSPVIQEEIVNDSDILPLFGDKAMGLVKPS 744
            |..:.|...||.|||:.|.::|.::::||....:.|..|:.||:..|..|||:|.:|.:|.|:..
Zfish   806 RTSVKGRIVTLGQFKELLTKKGSYKYYFKKVSYEFDCGVVFEEVREDDAILPIFEEKIIGKVEKV 870

  Fly   745 D 745
            |
Zfish   871 D 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	36/120 (30%)
		Axin_b-cat_bind	494..543	CDD:285982	19/52 (37%)
		DIX	665..739	CDD:279160	30/74 (41%)
axin1	XP_009297983.1	Axin_TNKS_binding	15..84	CDD:211424	12/58 (21%)
		RGS_Axin	93..212	CDD:188662	36/120 (30%)
		DUF507	368..>427	CDD:321349	18/61 (30%)
		Axin_b-cat_bind	469..504	CDD:312391	17/42 (40%)
		DIX	791..866	CDD:307085	29/74 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3535
OMA	1	1.010	-	-		QHG50119
OrthoDB	1	1.010	-	-		D1481971at2759
OrthoFinder	1	1.000	-	-		FOG0003472
OrthoInspector	1	1.000	-	-		oto38935
orthoMCL	1	0.900	-	-		OOG6_105312
Panther	1	1.100	-	-	O	PTHR46102
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2363
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980