Protein Alignment Axn and rgs12a

DIOPT Version :10

• Sequence 1: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: XP_699097.5
• Gene: rgs12a / 570516
• ZFINID: ZDB-GENE-030131-2614
• Length: 1371
• Species: Danio rerio
• Alignment Length: 870
• Identity: 175/870 - (20%)
• Similarity: 274/870 - (31%)
• Gaps: 298/870 - (34%)

  Fly     7 GIRKHDDNECSGPRPPVPGEESRVKKMTEGVADTSKNSS-PSYLN-----------WARTLNHLL 59
            |:::||   ||                  .|:....|.| ||..|           ||.:...||
Zfish   643 GVQRHD---CS------------------SVSSLDSNGSLPSVTNHCRFTERRVALWAVSFERLL 686

  Fly    60 EDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQ--QTDPEKIKQIIGAIY-RFL-RKSQLSIS 120
            :|..||..|.:::::|..  .:::.|:.|||...|  :.|.:::.|....|| ||| .|:.:.::
Zfish   687 QDPVGVRYFSEFLKKEFS--EENILFWQACECFSQVPEHDKKQLSQKAKEIYNRFLSSKATMPVN 749

  Fly   121 DDLRAQI-KAIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTS 184
            .|.:||: ..:.|.|:    |::|...|..:...::.:.|..||.|   .||.:.|.|:.|
Zfish   750 IDSQAQLADDVLTAPQ----PNMFKQPQLQIFNLMKMDSYARFLKS---TLYQECMLAEVE---- 803

  Fly   185 SGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSGPPAGTCS--- 246
                           |..|...|.:|.:.|..|.   ......:..:.|......|..|..|
Zfish   804 ---------------GRPLPDPCPIPCSPAPSKH---SFTSDRSTFSTPKKENRKPKTGRSSDDL 850

  Fly   247 ----------------------------------------------ASGSVYGPSTSASSS---- 261
                                                          :||:....:||.|..
Zfish   851 REKHSDKKNGFFSWYRYPSIGKGQKKREAPDLPYHCNGRRESQGSLSSGASQELNTSCSGGKNEQ 915

  Fly   262 ----GSISATD------------TLP--RSSTLPTLHEDSV----LSLCD----DFEKVQMQEGG 300
                ||..|.|            |||  .|.::|.....|:    |.||.    :...|.:...|
Zfish   916 CELRGSSCALDKERERCSRTCTVTLPDGSSCSIPLRQGASIRQVLLELCQKQHINLAAVDLFLTG 980

  Fly   301 GS----LGSGSVGAGARAPDYPIRLTR------DLLIATQKRRLEIRPPGAHGYVYNPSTTNTSY 355
            |.    |...|:...:|    .:||.:      ||:...:...|:.:|......|..|.......
Zfish   981 GEKPLVLDQDSITLSSR----ELRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGL 1041

  Fly   356 VPNSRVDSERASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSAMANKETNTFQVI 420
            .....|    |.:|  |.|:...:.:...::||...:..|  :..:||.:...:.:|.....:..
Zfish  1042 QLGDLV----ARIS--GETEVLDLGVPISNLDGLRVVLER--ADPAKAEKSKTLNSKTPAAKKGF 1098

  Fly   421 PRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNERSSASDRAFAEA 485
            || :|..::..:|||.:  |....|:....:||:..:....|......||:..:||..|......
Zfish  1099 PR-ERDDNSTVKPLKAD--VEDKHPRTAASERKKGKKNHIDETEEFFELLSRAQSSRVDDQRGLL 1160

  Fly   486 IREKFALDEDNDQDILDQHVSRVWKDQTPHRSPGTMSPCPPIPSRRRTATHDSGMVSDGAMSLSG 550
            .:|...|     .|.|     ||..|..|...|...:|....|....|.            |.:.
Zfish  1161 RKEDLVL-----PDFL-----RVNNDPKPQSPPSCSTPTSHKPGHTTTT------------STNP 1203

  Fly   551 HSMKHSKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTKYKDASSRSGSSTASKLEEAKRRL 615
            |.       |..|.|           |.....:.|||......:.|.:|.        :|.:..|
Zfish  1204 HP-------PKPSPC-----------NGHQASAPFSAPLSPILRSAGARE--------QEEEEGL 1242

  Fly   616 EDEPRRSRRYAQPPMQHLSQQPLASFSSSSSGGSISLPHQ---PPPLPAKPPE---TIVVFSFCE 674
            .|                        .:..:.|.||.|:.   |||.|..||.   ::...:|..
Zfish  1243 GD------------------------LTLVAEGDISSPNSTLLPPPPPVSPPPYDGSLAEANFTP 1283

  Fly   675 EPVPYRIKIPGT-----------------QPTLR----------QFKDYLP---------RRGHF 703
            .|.     :.||                 ||.||          .|:.|..         |.|
Zfish  1284 PPA-----VHGTGTEEENTSTSAVNSSTAQPDLRVRDKGVTLEDSFEGYAAELRQCQNKMRNG-- 1341

  Fly   704 RFFFKTHCEDPDSPVIQEEIVNDSD 728
             .:..|....|.|.|::   ||:||
Zfish  1342 -VYPSTDAPRPLSGVLE---VNESD 1362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:470619	32/119 (27%)
		Axin_b-cat_bind	495..530	CDD:462616	9/34 (26%)
		DIX	665..741	CDD:459936	20/103 (19%)
rgs12a	XP_699097.5	None