DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and Rgs6

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_038968710.1	Gene:	Rgs6 / 54295	RGDID:	3569	Length:	552	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	67/380 - (17%)
Similarity:	109/380 - (28%)	Gaps:	158/380 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PVPG----------------EESRVKKMTEGVADTSKNSSP--------------------SYLN 50
            ||||                ...:|||...||.|.|::.||                    ::||
  Rat   205 PVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTDESQSQSPVHIPSQPIRKTTKDDIRKQITFLN 269

  Fly    51 ---------------------------------------------------------------WA 52
                                                                           |.
  Rat   270 AQIDRHCLKMSKVAESLIAYTEQYVEYDPFITPAEPSNPWISDDITLWDIEMSKEPSQQRVKRWG 334

  Fly    53 RTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQTDPEKIKQIIGAIYRFLRKSQL 117
            .:.:.:|:|:.|.:.|.:::|.|..:.|  |.|:.|.:.||:|...:..|::......||.....
  Rat   335 FSFDEILKDQVGRDQFLRFLESEFSSEN--LRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAP 397

  Fly   118 SI----SDDLRAQIKAIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMY---ILYIQQM 175
            |.    |.......:.:|..     ..:.|:..|.|:...::.:.|..||.|..|   :|..::.
  Rat   398 SAINLDSHSYEITSQNVKDG-----GRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKP 457

  Fly   176 SAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTAS-----GKQQLPQLVPPGAFINLPVS 235
            .::|.|.||                        |...|.|     ..:......|.|.|:
  Rat   458 ESEQGRRTS------------------------LEKFTRSVCCWRRLRMAAAFHPRGGFL----- 493

  Fly   236 SVSGPPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDD 290
                |..|..:...:.|||.       ::..|..:|.|...||.|.....|..:|
  Rat   494 ----PAVGKVAGGQAPYGPD-------AVLLTAPIPGSGPGPTEHPGRRRSTSND 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	27/121 (22%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
Rgs6	XP_038968710.1	DEP_RGS7-like	31..119	CDD:239897
		RGS_DHEX	116..217	CDD:375589	4/11 (36%)
		GGL	258..319	CDD:128520	2/60 (3%)
		RGS_RGS6	328..452	CDD:188691	28/130 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900