Protein Alignment Axn and Rgs14

DIOPT Version :10

• Sequence 1: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_001347643.1
• Gene: Rgs14 / 51791
• MGIID: 1859709
• Length: 551
• Species: Mus musculus
• Alignment Length: 686
• Identity: 147/686 - (21%)
• Similarity: 232/686 - (33%)
• Gaps: 238/686 - (34%)

  Fly    17 SGPRPPVPGEESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYND 81
            |||..|...||..|                  .:||::...||:|..|:..|.:::::|..|.|
Mouse    48 SGPSSPFSTEEQPV------------------ASWAQSFERLLQDPRGLAYFTEFLKKEFSAEN- 93

  Fly    82 HLNFYFACEGLKQ--QTDPEKIKQIIGAIY-RFLRKSQLS---------ISDDLRAQIKAIKTNP 134
             :.|:.|||..:|  .:|.:::.|....|| .||....||         :|:::.||.:
Mouse    94 -VTFWKACERFQQIPASDTKQLAQEAHNIYHEFLSSQALSPVNIDRQAWLSEEVLAQPR------ 151

  Fly   135 EIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTSSGATGS--GSAGSSG 197
                 |.:|...|..:...::.:.|..|:.|.:|           :.|..:.|.|.  ...|||.
Mouse   152 -----PDMFRAQQLQIFNLMKFDSYARFVKSPLY-----------QECLLAEAEGRPLREPGSSH 200

  Fly   198 SGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSGPP--AGTC----------SASGS 250
            .|.          |.||..|.:|    .||..:.|.|..:...|  .|.|          ..:|.
Mouse   201 LGS----------PDTARKKPKL----KPGKSLPLGVEELGQLPLAEGPCGRPLRKSFRREMTGG 251

  Fly   251 VYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLGSGSVGAGARAP 315
            ....:....|.||:::      |::|.......|.|..:...|        |||||...:.:|
Mouse   252 AMNSALRRESQGSLNS------SASLDLGFLAFVSSKSESHRK--------SLGSGESESESR-- 300

  Fly   316 DYPIRLTRDLLIATQKRRLEIRPPGAHGYVYNPSTTNTSYVPNSRVDSERASVSSGGRTDSDTMS 380
                                   ||.:..||.|..|.:            .:::..|.|..| |.
Mouse   301 -----------------------PGKYCCVYLPDGTAS------------LALARPGLTIRD-ML 329

  Fly   381 ISSCSMDG--RPYIQRRHSSTESKAI----RQSAMANKETN-----TFQV----IPRTQRLHSNE 430
            ...|...|  .|.|:......|.||:    ..:.:|::|..     |||:    :.|..|:.:
Mouse   330 AGICEKRGLSLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLENRITFQLELVGLERVVRISA-- 392

  Fly   431 HRPLKE-EELVSLLIPK----LEEVKRKRDLEERARERNPGAALLTNERSSASDRAFAEAIREKF 490
             :|.|. :|.:..::.|    |::|...|..|::..:       |.|..||.:.        :..
Mouse   393 -KPTKRLQEALQPILAKHGLSLDQVVLHRPGEKQPMD-------LENPVSSVAS--------QTL 441

  Fly   491 ALDEDNDQDILDQHVSRVWKDQTPHRSPGTMSPCPPIPSRRRTATHDSGMVSDGAMSLSGHSMKH 555
            .||...|..:.:.      :..:|.||.|    |.|     ||.|.||
Mouse   442 VLDTPPDAKMSEA------RSISPCRSQG----CLP-----RTQTKDS----------------- 474

  Fly   556 SKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTKYKDASSRSGSSTASKLE------EAKRR 614
              .:|..||                  |:.       .:||||.:|:.....:|      .|:..
Mouse   475 --HLPPSSS------------------SLL-------VEDASSSTGNRQTCDIEGALPGGAAESG 512

  Fly   615 LEDEPRRSRRYAQPPMQHLSQQPLASFSSSS-SGGS 649
            .|....||.|.:.......|:...|||..:. ||||
Mouse   513 AEQRGPRSERTSSQRGPGPSRISAASFPKTRLSGGS 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:470619	31/126 (25%)
		Axin_b-cat_bind	495..530	CDD:462616	7/34 (21%)
		DIX	665..741	CDD:459936
Rgs14	NP_001347643.1	RGS_RGS14	58..186	CDD:188697	36/169 (21%)
		RBD1_RGS14	303..373	CDD:340657	17/82 (21%)
		RBD2_RGS14	374..446	CDD:340659	19/89 (21%)