Protein Alignment Axn and loco

DIOPT Version :10

• Sequence 1: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Alignment Length: 808
• Identity: 146/808 - (18%)
• Similarity: 278/808 - (34%)
• Gaps: 217/808 - (26%)

  Fly    22 PVPGEESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFY 86
            |.|..........||.|  ..:..||  :||.:...:|:|..|::.|.:::::|..|.|  :.|:
  Fly   799 PAPPSAITASVAAEGAA--QDHGCPS--SWAGSFERMLQDAAGMQTFSEFLKKEFSAEN--IYFW 857

  Fly    87 FACEGLK-QQTDPEKIKQIIGAIYRFLRKSQLSISD--DLRAQIKAIKTNPEIPLSPHIFDPMQR 148
            .|||..: .:::.:::.|......:.|..:.   ||  ::.:|.:::........:|.||.|.|:
  Fly   858 TACERYRLLESEADRVAQAREIFAKHLANNS---SDPVNVDSQARSLTEEKLADAAPDIFAPAQK 919

  Fly   149 HVEVTIRDNIYPTFLCSEMYILYIQQMSAQQ----------ERCTSSGATGSGS-AGSSGSGGSS 202
            .:...::.:.|..|:.|::|...::.....|          |...::...|:.| ...|.|....
  Fly   920 QIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKSASNAED 984

  Fly   203 LAGACALP-----------PTTASGKQQLPQLVPPGAFINLPVSSVSGPPAGTCSASGSVYGPST 256
            ......||           .|......|...:..|....|.|::|.|.......::...::...:
  Fly   985 RRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQNSLSDLHSSRS 1049

  Fly   257 SASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLGSGSVGAGARAPDYPIRL 321
            |.||..:.:||.....|:       :||.|||    :|.:.:|..::      ...|..:....|
  Fly  1050 SLSSFDAGTATGGQGAST-------ESVYSLC----RVILTDGATTI------VQTRPGETVGEL 1097

  Fly   322 TRDLLIATQKRRLEIRPPGAHGYVYNPSTTNTSYVPNSRVDSERASVSSGGR------------- 373
            ...||   :||.| :.|  .:..|:..||.:        :|.::.|....|:
  Fly  1098 VERLL---EKRNL-VYP--YYDIVFQGSTKS--------IDVQQPSQILAGKEVVIERRVAFKLD 1148

  Fly   374 -TDSDTMSISSCSMDG-----RPYIQRRHSSTESKAI------------RQSAMANKE------- 413
             .|...:|:.|.....     ||.:.:.:...|...:            :...||:.:
  Fly  1149 LPDPKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMV 1213

  Fly   414 TNTFQV-----IPRTQRLHSNEHRPLKE---EELVSLLIPKLEEVKRKRDLEERARERNPGAALL 470
            .:.|||     :|..|   |...:||.:   :||.:.:..:|...|......|::|..:. .::.
  Fly  1214 NSDFQVGGGSSMPPKQ---SKPMKPLPQGHLDELTNKVFNELLASKADAAASEKSRPVDL-CSMK 1274

  Fly   471 TNERSSASDRAFAEAIREKFALDEDNDQDILDQHVSRVWKDQTPHRSPGTMSPCPPIPSRRRTAT 535
            :||..|.:...|....|::                          |..|.: |...:|..::.:|
  Fly  1275 SNEAPSETSSLFERMRRQQ--------------------------RDGGNI-PASKLPKLKKKST 1312

  Fly   536 HDSGMVSDGAMS--------------LSGHSMKHSKSMPDH----------SSCSRKLTNKWPSM 576
            ..|....:.|.:              .:|..::.::.:.:|          :..:|....:...:
  Fly  1313 SSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQRGTEI 1377

  Fly   577 NTDSGISMFSADTVTKYKDASSRSGSSTASKLEEAKRRL--------------EDEPRRSRRYAQ 627
            |       |......|.|:    :.|:..|||.:.:..|              :..||.|...:|
  Fly  1378 N-------FDLPDFLKNKE----NLSAAVSKLRKVRASLSPVSKVPATPTEIPQPAPRLSITRSQ 1431

  Fly   628 PPM--QHLSQQPLASFSSSSSGGSISLPHQPPPLPAKPPETIVVFSFCEEPVPYRIKIPG-TQPT 689
            .|:  ..:.|:|.....:::. ........|||||.||           :.:|.:....| .|||
  Fly  1432 QPVSPMKVDQEPETDLPAATQ-DQTEFAKAPPPLPPKP-----------KVLPIKPSNWGVAQPT 1484

  Fly   690 LRQFKDYLPRRGHFRFFFKTHCEDPDSP 717
            ......|.|.:           :.|.||
  Fly  1485 GNYCNKYSPSK-----------QVPTSP 1501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:470619	25/117 (21%)
		Axin_b-cat_bind	495..530	CDD:462616	4/34 (12%)
		DIX	665..741	CDD:459936	10/54 (19%)
loco	NP_732773.1	PDZ_RGS12-like	70..145	CDD:467194
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	25/117 (21%)
		RBD1_RGS12_like	1072..1141	CDD:340515	19/92 (21%)
		RBD2_RGS12_like	1142..1212	CDD:340587	8/69 (12%)
		GoLoco	1354..1375	CDD:214645	1/20 (5%)