DRSC/TRiP Functional Genomics Resources

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Protein Alignment Axn and GRID2IP

DIOPT Version :9

Sequence 1:NP_733336.1 Gene:Axn / 43565 FlyBaseID:FBgn0026597 Length:745 Species:Drosophila melanogaster
Sequence 2:NP_001138590.1 Gene:GRID2IP / 392862 HGNCID:18464 Length:1211 Species:Homo sapiens


Alignment Length:559 Identity:113/559 - (20%)
Similarity:163/559 - (29%) Gaps:191/559 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   271 PRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLGSG--------------SVGAGARAPDYPIRL 321
            ||||...:       |:|....:.|..|.|.|.|..              ..|.|...|:.|...
Human   493 PRSSLRAS-------SMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGDGTSLPETPNPK 550

  Fly   322 TRDLLIATQKRRL--------------EIRPPGAHGYV----------------------YNP-- 348
            ....:.|..:.||              ...|||....|                      |:|  
Human   551 MMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLC 615

  Fly   349 -----STTNTSYVPNSRVDSERASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSA 408
                 |.:::...|.:.:||.||.....|  .......|..|.|......||...|.|..:|   
Human   616 SGGLASPSSSESHPYASLDSSRAPSPQPG--PGPICPDSPPSPDPTRPPSRRKLFTFSHPVR--- 675

  Fly   409 MANKETNTF------QVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGA 467
              :::|:.|      |:.||...:.             ..|.|       :.|.||.:...:.| 
Human   676 --SRDTDRFLDVLSEQLGPRVTIVD-------------DFLTP-------ENDYEEMSFHDDQG- 717

  Fly   468 ALLTNERSSASDRAFAEAIREKFALDEDNDQDILDQHVSRVWKDQTPHRSPGTMSPCPPIPSRRR 532
            :.:|||||||||...:.                 ::..|..:...:.|..|..:||.||.|    
Human   718 SFVTNERSSASDCISSS-----------------EEGSSLTYSSISDHIPPPPLSPPPPPP---- 761

  Fly   533 TATHD---SGMVSDG---------------------------------AMSLSGHSMKHSKSMPD 561
            ...||   |...|||                                 |..:....:.|.:|...
Human   762 LPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSRGLGHRRSETS 826

  Fly   562 HSSCSR----KLTNK----WPSMNTDSGISMFSADTVTKYKDASSRSGSSTASKLEEAKRRLEDE 618
            |.|..|    ::.|.    |..:..||.....|  .:.||.|.....|:.     :.||.....|
Human   827 HMSVKRLRWEQVENSEGTIWGQLGEDSDYDKLS--DMVKYLDLELHFGTQ-----KPAKPVPGPE 884

  Fly   619 PRRSRRYAQPPMQHLSQQPLASFSSSSSGGSISLPHQPPPLPAKPPETIVVFSFCEEPVPYRIKI 683
            |.|.:...: .:.|          ..:...||.|.|    |...|.|...|....|   |.|:: 
Human   885 PFRKKEVVE-ILSH----------KKAYNTSILLAH----LKLSPAELRQVLMSME---PRRLE- 930

  Fly   684 PGTQPTLRQFKDYLPRRGHFRFFFKT--HCEDPDSPVIQ 720
            |.....|..|.........::.|.:.  ...:||..|:|
Human   931 PAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQ 969

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AxnNP_733336.1 RGS 55..170 CDD:295367
Axin_b-cat_bind 494..543 CDD:285982 11/51 (22%)
DIX 665..739 CDD:279160 13/58 (22%)
GRID2IPNP_001138590.1 PDZ_signaling 14..74 CDD:238492
HN_L-delphilin-R1_like 133..212 CDD:259820
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..269
PDZ_signaling 278..353 CDD:238492
HN_L-delphilin-R2_like 389..468 CDD:259821
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..502 4/15 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..549 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..600 4/31 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..672 13/55 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..783 23/85 (27%)
FH2 820..1188 CDD:280362 39/176 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3589
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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