Protein Alignment Axn and rgs12b

DIOPT Version :10

• Sequence 1: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_999889.1
• Gene: rgs12b / 378970
• ZFINID: ZDB-GENE-031006-13
• Length: 1540
• Species: Danio rerio
• Alignment Length: 869
• Identity: 168/869 - (19%)
• Similarity: 269/869 - (30%)
• Gaps: 305/869 - (35%)

  Fly    38 ADTSKNSSPS--------------YLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFA 88
            :|.|.||:.|              ..:||.....||:|..||..|.:::::|..  .:::.|:.|
Zfish   710 SDNSLNSNASLPSVQCHRRHTERRVASWAVCFERLLQDPVGVRYFSEFLKKEFS--EENILFWQA 772

  Fly    89 CEGLKQ--QTDPEKIKQIIGAIYR-FL-RKSQLSISDDLRAQI-KAIKTNPEIPLSPHIFDPMQR 148
            ||....  :||.:::.|....||. || .|:...::.|.:||: ..|...|.    |.:|...|.
Zfish   773 CEYFSHVPETDKKQLSQRAREIYNSFLSSKATTPVNIDSQAQLADDILNAPR----PDMFKEQQL 833

  Fly   149 HVEVTIRDNIYPTFLCSEMYILYIQQMSAQQE------------RCTSSGATGS----------- 190
            .:...::.:.|..||.|   .||.:.|.|:.|            ..||..:|||
Zfish   834 QIFNLMKFDSYTRFLKS---YLYQECMLAEVEGRPLPDPYQVPSSPTSKHSTGSDRSNLSTPKKV 895

  Fly   191 ----------------------------------------------------GSAGSSGSGGSSL 203
                                                                ||.|...|.||..
Zfish   896 QDDKKSKSGRSLNEDSRDEHGDKKKSIFFSWSRNRSFGKGSKKRDLADYSFTGSNGRRESQGSLS 960

  Fly   204 AGACALPPTTASGKQQ---------LPQLVPPGAFINLPVSSVSGPP-----------AGTCSAS 248
            :||.....|:.|||.:         |.:.......||||..|....|           .|.|...
Zfish   961 SGASLELATSGSGKNEGEVSRNSMSLSERAVRHCNINLPDGSCCSVPIRPGVSIREVLLGLCEKL 1025

  Fly   249 GSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCD-------------DFEKVQMQEGG 300
            |.            :::|.|........|.:.:...::||.             |...:
Zfish  1026 GI------------NLAAVDLFLVGGEKPLVLDQDCMTLCSRDLRLEKRTLFRLDLVPI------ 1072

  Fly   301 GSLGSGSVGAGARAPDYPIR-----------LTRDLLIAT---QKRRLEIRPPGAHGYVYNPSTT 351
                :.|||..|: |..|:.           |....|:||   :|..|::.
Zfish  1073 ----NRSVGLKAK-PTKPVTEVLRPVVAKYGLNLGDLVATISGEKEPLDLG-------------- 1118

  Fly   352 NTSYVPNSRVDSERASVSSGGR-TDSDTMSISSCSMDGRPYIQRRHSST-------ESKAIRQSA 408
                :|.|.:|..|..:.:|.. :..|...:.|....|.|...|..|:|       ::.|::..|
Zfish  1119 ----LPISNLDGLRVVLEAGDHVSGKDKQKLVSSKSHGPPLSTRSQSATGEDKTAGKASAVKTRA 1179

  Fly   409 MANKETNT----------FQVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRD-------- 455
            ...|....          |::|.:.|...:::.|.|..:.  .|::|....:..:.|
Zfish  1180 QVEKRKQKKLNIDEAEEFFELISKAQSNRADDQRGLLNKS--DLVLPDFLRLDTEADGNNLSSTP 1242

  Fly   456 --LEERARERNPGAALLTNERSSASDRAFAEAIREKFALDEDNDQDILDQHVSRVWKDQTPHRSP 518
              .:.|.|.:..|:||..:.::.:.|.| .|....:.||...|  ..|....||:        .|
Zfish  1243 ISHKTRPRSKENGSALSASHQTQSLDSA-GEGKAPRRALMPPN--SALRNTSSRI--------PP 1296

  Fly   519 GTMSPCPPIPSRRRTAT-----------------HDSGM----VSDGAMSLSGHSMKHSKSMPDH 562
            ...|...|||..:...:                 .:|||    |::|.::....|:.|...:|..
Zfish  1297 PFSSSLSPIPHSQMGGSSGITDWRSDGGVQALEEEESGMDLTFVAEGDITSPNSSLLHQSPIPLP 1361

  Fly   563 SSCSRKLTNKWPSMNTDSGISMFSADTVTKYKDASSRSGSSTASKLEEAKRRLEDEPRRSRRYAQ 627
            .|..|.              .:...||.   :|:.:|||......:...:.|........|
Zfish  1362 PSPERS--------------HLLKEDTC---QDSWARSGGLMTKTVVSNRNRFSSVKNERR---- 1405

  Fly   628 PPMQHLSQQPLASFSSSSSGGSISLPHQPPPLPAKPPETIVVFSFCEEPVPYRIKIPGTQPTLRQ 692
                   |:...|.|..|...:.|.|..|||.|...|.:          .|.|::..|.:..|
Zfish  1406 -------QRDRTSVSKYSHRRAPSAPPPPPPHPPPAPPS----------APPRVRGAGKRSPL-- 1451

  Fly   693 FKDYLPRRGHFRFFFKT---HCED 713
                     |.|.....   ||.|
Zfish  1452 ---------HVRGALDVDGIHCGD 1466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:470619	31/119 (26%)
		Axin_b-cat_bind	495..530	CDD:462616	9/34 (26%)
		DIX	665..741	CDD:459936	9/52 (17%)
rgs12b	NP_999889.1	PDZ_RGS12-like	21..96	CDD:467194
		PTB_RGS12	239..372	CDD:269984
		RGS_RGS12	741..855	CDD:188696	33/122 (27%)
		RGS12_us1	861..973	CDD:465199	15/111 (14%)
		RBD1_RGS12	992..1061	CDD:340656	14/80 (18%)
		RBD2_RGS12	1062..1134	CDD:340658	17/100 (17%)
		RGS12_us2	1136..1193	CDD:435461	10/56 (18%)
		GoLoco	1195..1216	CDD:214645	4/20 (20%)
		RGS12_usC	<1323..1374	CDD:465198	10/64 (16%)