DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and rgs14a

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_009305919.2	Gene:	rgs14a / 327368	ZFINID:	ZDB-GENE-030131-5579	Length:	554	Species:	Danio rerio

Alignment Length:	562	Identity:	118/562 - (20%)
Similarity:	200/562 - (35%)	Gaps:	148/562 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SGHPSGIRKHDDNEC----SGPRPPV--------PGEESRVKK---------MTEGVAD------ 39
            :|....:||.....|    .|.|..:        |.|:...|.         ||:.|:|
Zfish     8 TGSDRAVRKRLSRRCVCLRGGFRESLSLWAQSCQPDEDMSKKMSSLAVPTGLMTQAVSDGELNLR 72

  Fly    40 ---------TSKNSSPS------------YLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHL 83
                     .|::||.|            .::||....|||||..||..|.:::..|..|.|  :
Zfish    73 LSSCGSSSSLSESSSRSGGSQAADGPASRVVSWAVCFEHLLEDHVGVRYFTEFLRSEVSAEN--I 135

  Fly    84 NFYFACEGLKQ--QTDPEKIKQIIGAIY-RFLRKSQL---SISDDLRAQIKAIKTNPEIPLSPHI 142
            .||.|||..|:  .:..|::|:....|| .||.:|.|   :|.|..:.:.:.:    |:| :|.:
Zfish   136 LFYQACEKFKKIPTSRLEEMKKEARLIYDTFLSESSLHAVNIDDTAQTEEREL----EMP-TPDM 195

  Fly   143 FDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTSSGATGSGSAGSSGS--GGSSLAG 205
            |:..|..:...::.:.|..|:.|.:|           :.|..: ...|....|.|:  ..|.::.
Zfish   196 FNKAQAQIFKLMKMDSYTRFVRSPLY-----------QNCMLA-CVESRPLPSIGTPEPKSKMSK 248

  Fly   206 ACALPPTT--------------ASGKQQLPQLVPPGAFINLPVSSVSGPPAGTCSASGS----VY 252
            ..|.||:.              .|.|::|......||..:....:||...:.....|.|    |.
Zfish   249 KSATPPSNRKSVELKVPSSDSKTSRKKRLENRGSWGADQSFERMAVSRKESQISVKSNSSLELVS 313

  Fly   253 GPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLGSGSVGAG------ 311
            |...:.:...|::.:|....||..||         .|.:..|.:.:|..||.|...|..
Zfish   314 GSGRAENGRCSVAVSDPEALSSGSPT---------ADKYCCVYLPDGTASLVSARAGLSLRDMIS 369

  Fly   312 ----------------ARAPDYPIRLTRDL-LIATQKRRLEIRPPGAHGYVYNPSTTN------- 352
                            .|..|.|:.|.:|. :...|:..||::...|....:...|..
Zfish   370 SLCEKRAFPLRDVLLYLRGKDKPLSLDQDCSMFGDQQLSLELKITFALEIAFLGRTIGIIAKSSK 434

  Fly   353 ------TSYVPNSRVDSERASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSAMAN 411
                  :|.:...::..:...:|..|..|:..||.|...:..:. ::...::.|.:....||.||
Zfish   435 SVGEALSSVLEKQQLRPQDVQLSLSGSNDALNMSTSVFRLANKT-VRLDRAALEIQTSSPSARAN 498

  Fly   412 KETNTFQ-------VIPRTQRLHSNEHRPLKEEELVSLLIPK 446
            ......|       ::.|.|...:::.|.|..:|  .|.||:
Zfish   499 SRGRKHQDVDGLVELLNRAQCSRADDQRGLLTKE--QLEIPQ 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	36/120 (30%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
rgs14a	XP_009305919.2	RGS_R12-like	109..223	CDD:188661	36/131 (27%)
		RGS12_RBD	343..415	CDD:176412	14/71 (20%)
		TGS	423..483	CDD:330245	8/60 (13%)
		GoLoco	508..529	CDD:308026	3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900