DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and Rgs9

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_062097.1	Gene:	Rgs9 / 29481	RGDID:	3572	Length:	677	Species:	Rattus norvegicus

Alignment Length:	298	Identity:	62/298 - (20%)
Similarity:	105/298 - (35%)	Gaps:	75/298 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQTDPEKIKQIIGAIYRFLRKS 115
            ||...:.|:.|..|.:.|:.::::|....|  |.|:.|||.|| ..|..|:|:....||:
  Rat   296 WAFNFSELIRDPKGRQSFQYFLKKEFSGEN--LGFWEACEDLK-YGDQSKVKEKAEEIYK----- 352

  Fly   116 QLSISDDLRAQIKAIKTNPEIPLS----PH--IFDPMQRHVEVTIRDNIYPTFLCSEMY------ 168
             |.::...|..|.......:|.:.    ||  :.|..|.|:.:.::.:.|..:|.|.:|
  Rat   353 -LFLAPGARRWINIDGKTMDITVKGLRHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYKEMLAK 416

  Fly   169 --------------------------ILYIQQMSAQQERCTSSGATGSGSAGSSGSGGSSLA--- 204
                                      .:.::|:..::....::........|...:....||
  Rat   417 AIEPQETTKRSSTLPFMRRHLRSSPSPVILRQLEEEERAREAANTVDITQPGQHLAPSPHLAVYT 481

  Fly   205 GACALP-------PTTASGKQQLPQLVPPGAFINLPVSSVSGPP-------------AGTCSASG 249
            |.|..|       |:..|.::..|.   |..||..|..::...|             .|..|.||
  Rat   482 GTCVPPSPSSPFSPSCRSPRKPFPS---PSRFIRRPSIAICPSPIRVALEGSSGLEGKGEASWSG 543

  Fly   250 SVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSL 287
            :..||..:.|...|:..  :.|.|.....|...:.|||
  Rat   544 ANPGPPVTESIETSVDR--SRPHSQPRAPLKARAALSL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	31/152 (20%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
Rgs9	NP_062097.1	DEP_RGS7-like	22..109	CDD:239897
		GGL	219..280	CDD:128520
		RGS_RGS9	292..412	CDD:188693	33/124 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..571		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900