DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axn and Axin2

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_077331.1	Gene:	Axin2 / 29134	RGDID:	69259	Length:	838	Species:	Rattus norvegicus

Alignment Length:	949	Identity:	210/949 - (22%)
Similarity:	335/949 - (35%)	Gaps:	331/949 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSGIRKHDDNECSGPRPPVPGEE----------------------SRVKKMTEGVADTSKNSSPS 47
            ||...:.|     .|||||||||                      |..::..:|:.:....:||.
  Rat    13 PSSSFRED-----APRPPVPGEEGETPPCQPSVGKVQSTKPMPVSSNARRNEDGLGEPEGRASPD 72

  Fly    48 --YLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQT-DPEKIKQIIGAIY 109
              ...|.::|:.||.|:||..||:.::|.|...  |.|:|:|||.|.:|.. ...|..::..|||
  Rat    73 SPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCV--DTLDFWFACNGFRQMNLKDTKTLRVAKAIY 135

  Fly   110 RFLRKSQLSISDDLRAQIK-----AIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYI 169
            :...::...:|..|:...|     .||..   .:...:||..|..::..:.:|.|..||.|::|:
  Rat   136 KRYIENNSVVSKQLKPATKTYIRDGIKKQ---QIGSVMFDQAQTEIQAVMEENAYQVFLTSDIYL 197

  Fly   170 LYIQQMSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPV 234
            .|::           ||  |..:|..|..|..||...|...||....::
  Rat   198 EYVR-----------SG--GENTAYMSNGGLGSLKVLCGYLPTLNEEEE---------------- 233

  Fly   235 SSVSGPPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEG 299
                    .||:.......|:....||.::.||.::..:.|..           :.|...:..|.
  Rat   234 --------WTCADLKCKLSPTVVGLSSKTLRATASVRSTETAE-----------NGFRSFKRSEP 279

  Fly   300 GGSLGSGSVGAGARAPDYPIRLTRDLLIATQKRRLEIRPPGAHGYVYNPSTTNTSYVPNSRVDSE 364
            ......||                                   |||:.|:|        |..|||
  Rat   280 VNPYHVGS-----------------------------------GYVFAPAT--------SANDSE 301

  Fly   365 RASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSAMANKETNTFQVIPRTQRLHSN 429
               :||...|| |:||::..|:||.|..:........:.:.:|..||.:. :....|||.|| ..
  Rat   302 ---LSSDALTD-DSMSMTDSSVDGIPPYRMGSKKQLQREMHRSVKANGQV-SLPHFPRTHRL-PK 360

  Fly   430 EHRPLKEEELVSLLIPKLE----EVKRKRDLEERARERNPGAALLTNERSSASDRAFAE----AI 486
            |..|::.....:.||.:||    |::.:..||||.::      :..:|....|::|.:.    .:
  Rat   361 EMTPVEPAAFAAELISRLEKLKLELESRHSLEERLQQ------IREDEEKEGSEQALSSRDGAPV 419

  Fly   487 REKFAL-----DEDNDQDILDQHVSRVWKD---QTP--------HRSP----------------- 518
            :...||     .|::.|.|||.|:|||.|.   |:|        .|||
  Rat   420 QHPLALLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHQQCHALLPTG 484

  Fly   519 GTMSP-------------------------------------------------CP--------- 525
            |.:.|                                                 ||
  Rat   485 GKLPPEAACPLLGGKSFLTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYCYS 549

  Fly   526 ----------PIPS------------RRRTATHDSGMV----------SDGAMSLSG-------- 550
                      |:|.            :|.|...:.|:.          :.||..|.|
  Rat   550 KCKSHSKPPEPLPGEQFCGSRGGTLPKRNTKGTEPGLALPAREGGMSSAAGAPQLPGEEGDRSQD 614

  Fly   551 ------HSMKHSKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTKY----KDASSRSGS--- 602
                  .|.:.|||.| ||:.|.:.:....|.....|      :.|:::    .....||.:
  Rat   615 VWQWMLESERQSKSKP-HSTQSIRKSYPLESARAPPG------ERVSRHHLLGASGHPRSAARAH 672

  Fly   603 --------------STASKLEEAKRRLED--EPRRSR---RYAQPPMQH--LSQQPLASFSSSSS 646
                          :|.::||||.|||.:  :|::.|   ...|....|  ..|....|||:.|.
  Rat   673 PFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCCVASQQRDRNHPATGQAGPTSFSNPSL 737

  Fly   647 GGSISLPHQPPPLPA-----KPPETIVVFSFCEEPVPYRIKIPGTQPTLRQFKDYLPRRGHFRFF 706
            .   |..|:.|...|     :..|.||.:.||.|.:|||..:.....||..||:.|.::|::|::
  Rat   738 A---SEDHKEPKRLASVHALQASELIVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYY 799

  Fly   707 FKTHCEDPDSPVIQEEIVNDSDILPLFGDKAMGLVKPSD 745
            ||...::.....:.|||.:|..:||::..:.:|.|:..|
  Rat   800 FKKASDEFACGAVFEEIWDDETVLPMYEGRILGKVERID 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	36/120 (30%)
		Axin_b-cat_bind	494..543	CDD:285982	24/166 (14%)
		DIX	665..739	CDD:279160	24/73 (33%)
Axin2	NP_077331.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		16/66 (24%)
		Axin_TNKS_binding	12..73	CDD:211424	16/64 (25%)
		Tankyrase-binding motif	21..30		7/8 (88%)
		RGS_Axin	82..198	CDD:188662	36/120 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..333		13/36 (36%)
		Interaction with GSK3B. /evidence=ECO:0000250	327..413		22/93 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..435		6/36 (17%)
		Interaction with beta-catenin. /evidence=ECO:0000250	413..476		17/62 (27%)
		Axin_b-cat_bind	433..468	CDD:400956	13/34 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..483		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..682		20/120 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..744		9/34 (26%)
		DAX	756..838	CDD:197474	26/81 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9392
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I3959
OMA	1	1.010	-	-		QHG50119
OrthoDB	1	1.010	-	-		D1481971at2759
OrthoFinder	1	1.000	-	-		FOG0003472
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105312
Panther	1	1.100	-	-	LDO	PTHR46102
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2363
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.980