DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axn and Grid2ip

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_006248928.1	Gene:	Grid2ip / 288484	RGDID:	1310492	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	139/691 - (20%)
Similarity:	214/691 - (30%)	Gaps:	253/691 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGPRPPVPGEESRV--KKMTEGVADTSKNSSPSYLNW----------------ARTLNHLL--ED 61
            ||..|.:..||..|  ...::.:...::.|:.:.|.|                ::.|:|||  .:
  Rat   333 SGAMPTLVVEEGPVPFASDSDSLDSPTRASALTSLQWVADILPSSIRVQGRTFSQQLDHLLTPPE 397

  Fly    62 RDGV----ELFKK-----------YVEEEAPAYNDHLNF-YFACEGLKQQTDPEKIKQIIGAIYR 110
            |.||    |.|.:           |...:.||......| |......:|:...|||...:|  |.
  Rat   398 RYGVCRALESFFQHRSIDTLIVDVYPVLDTPAKQVLWQFLYQLLTYEEQELCQEKIACFLG--YT 460

  Fly   111 FLRKSQLSISDDLRAQIKAIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQM 175
            .:.:.:.|:  ||..:     :.||....|   .|         |.::..:.:|
  Rat   461 AITEPESSL--DLEPE-----STPEPTPEP---QP---------RSSLRASSMC----------- 495

  Fly   176 SAQQERCTSSGATGSGSAGSSGSGGSSLAGACA-LPPTTASGKQQLPQLVPPGAFINLPVSSVSG 239
               :....|.|...|.|.|         .|.|: :|.....|::|      .|...:||.:
  Rat   496 ---RRSLRSQGLEASLSCG---------PGDCSEMPLPLIPGERQ------AGDGTSLPET---- 538

  Fly   240 PPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLG 304
            |.....||   ||....|..:||......|:.:|...|     .|.||.            |:.|
  Rat   539 PNPKMMSA---VYAELESRLNSGFKGKIGTVSKSRASP-----PVPSLV------------GTSG 583

  Fly   305 ----SGSVGAGAR---APDYPIRLTRDLLIATQKRRLEIRPPGAHGYVYNPSTTNTSYVPNSRVD 362
                ||....|.|   :|.|                    .|...|.:.:||::.:.  |.:.:|
  Rat   584 PRTLSGVSWPGDRLLPSPCY--------------------DPLCSGGLASPSSSESH--PYASLD 626

  Fly   363 SERASVSSGGRTDSDTMSISSCSMDGRPY------IQRRHSSTESKAIRQSAMANKETNTF---- 417
            |.||.....|        :.|...|..|.      ..||.....|:.:|     :::|:.|
  Rat   627 SSRAPSPQPG--------LGSIHPDSPPSPDPIRPPSRRKLFAFSRPVR-----SRDTDRFLDVL 678

  Fly   418 --QVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNERSSASDR 480
              |:.||...:.             ..|.|       :.|.||.:...:.| :.:||||||||:.
  Rat   679 SEQLGPRVTIVD-------------DFLTP-------ENDYEEMSFHDDQG-SFVTNERSSASEC 722

  Fly   481 AFAEAIREKFALDEDNDQDILDQHVSRVWKDQTPHRSPGTMSPCPPIPSRRRTATHD---SGMVS 542
            ..:.                 ::..|..:...:.|..|..:||.||.|    ...||   |...|
  Rat   723 VSSS-----------------EEGSSLTYSSISDHIPPPPLSPPPPPP----LPFHDPKPSSRTS 766

  Fly   543 DG---------------------------------AMSLSGHSMKHSKSMPDHSSCSR----KLT 570
            ||                                 |..:....:.|.:|...|.|..|    ::.
  Rat   767 DGPRGPPQSLTKPLTQISHPVPPPPPPPLPPPVPCAPPMISRGVGHRRSETSHMSVKRLRWEQVE 831

  Fly   571 NK----WPSMNTDSGISMFSADTVTKYKDASSRSGSSTASK 607
            |.    |..:..||.....|  .:.||.|.....|:....|
  Rat   832 NSEGTIWGQLGEDSDYDKLS--DMVKYLDLELHFGTQKPPK 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	29/132 (22%)
		Axin_b-cat_bind	494..543	CDD:285982	11/51 (22%)
		DIX	665..739	CDD:279160
Grid2ip	XP_006248928.1	PDZ_signaling	9..69	CDD:238492
		HN_L-delphilin-R1_like	122..201	CDD:259820
		PDZ_signaling	269..342	CDD:238492	3/8 (38%)
		HN_L-delphilin-R2_like	378..457	CDD:259821	18/78 (23%)
		FH2	812..1180	CDD:280362	15/61 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900