DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axn and Rgs2

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_033087.2	Gene:	Rgs2 / 19735	MGIID:	1098271	Length:	211	Species:	Mus musculus

Alignment Length:	175	Identity:	45/175 - (25%)
Similarity:	74/175 - (42%)	Gaps:	19/175 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGPRPPVPGEESRVKKMTEGVADTSKNSSPSYLN-WARTLNHLLEDRDGVELFKKYVEEEAPAYN 80
            |.|..|..|::|:        ..|....||.... ||...:.||..:.|:..|:.:::.|  ...
Mouse    53 SAPGKPKTGKKSK--------QQTFIKPSPEEAQLWAEAFDELLASKYGLAAFRAFLKSE--FCE 107

  Fly    81 DHLNFYFACEGLKQQTDPEKIKQIIGAIYR-FLRK-SQLSISDDLRAQIKAIKTNPEIPLSPHIF 143
            :::.|:.|||..|:...|:|:......||. |:.| :...|:.|.  |.|::........:...|
Mouse   108 ENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDF--QTKSLIAQNIQEATSGCF 170

  Fly   144 DPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTSSGAT 188
            ...|:.|...:.:|.||.||.||.|    |.:..:.:..|...||
Mouse   171 TTAQKRVYSLMENNSYPRFLESEFY----QDLCKKPQITTEPHAT 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	31/116 (27%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
Rgs2	NP_033087.2	Necessary for membrane association. /evidence=ECO:0000250\|UniProtKB:P41220	32..66		5/20 (25%)
		Necessary to inhibit protein synthesis. /evidence=ECO:0000250\|UniProtKB:P41220	79..116		8/38 (21%)
		RGS_RGS2	84..197	CDD:188664	31/120 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900