DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axn and rgs-6

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001294820.1	Gene:	rgs-6 / 180840	WormBaseID:	WBGene00004349	Length:	734	Species:	Caenorhabditis elegans

Alignment Length:	792	Identity:	157/792 - (19%)
Similarity:	255/792 - (32%)	Gaps:	255/792 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 CSGPRPPVPGEES-------RVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGV--ELFKKY 71
            |||..|..|...|       ....|..|||....|||.....:.:.:      ||.|  ..|:::
Worm     5 CSGNEPATPTNTSPNNETSNSCLSMGVGVASNETNSSRELKIFKKVI------RDPVLRAPFQEF 63

  Fly    72 VEEEAPAYNDHLNFYFACEGLKQQTDPEKI----KQIIGAIYRFLRKSQLSISDDLRAQIKAIKT 132
            :|::..|.|  ||||.|.|..|:..|.::.    ::|....:.......::|.:....:|:....
Worm    64 LEQQFCAEN--LNFYLAVEQFKEIQDFQERSSFGRRIFDRYFAMNSTEPVNIDNSTSKRIRETVE 126

  Fly   133 NPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTSSGATGSGSAGSSG 197
            :...||.  .:|..|..:...::.:.:|.||.|...    .|.|...|...:.....:|.:..:.
Worm   127 SGGFPLD--TYDVAQYQILHLLKYDCWPRFLRSTNN----SQPSFTDEELAADDEDKNGHSQPTS 185

  Fly   198 SGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSGPPAGTCSASGSVYGPSTSASSSG 262
            ...::...|.|          |..|..|     |.|.::...|     |...|:....||.....
Worm   186 LNNTNEFEAAA----------QQSQPAP-----NAPAATKEKP-----SKQYSMPAEMTSPVKKN 230

  Fly   263 SISATDTLPRSSTLPTLH---------EDSVLSLCDDFEKVQ--MQEGGGSLG------------ 304
            |:|.|. |.|...:...|         ....::|.|....|:  .||...:.|
Worm   231 SLSPTH-LRRCRPVEPKHCQLMIGDQFNTETVTLSDPTMSVRRWTQEMADAQGMDRMHVEVVDAE 294

  Fly   305 SGSVGAGARAPDYPIRLTRDLLIATQKRRLEIRP---------PGAHGYVYNPSTTNTSYVPNSR 360
            :||.          |...|..:.|.|.|.|.:.|         |....: .||::|.|..|
Worm   295 TGST----------IDPARQAIDALQSRALRLVPVVSFIIEFLPANFSF-KNPASTPTKLV---- 344

  Fly   361 VDSERASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSAMANKETNTFQVIPRTQR 425
                                   |       |:.|||.:....:|  .:.:|.|    :.|:..|
Worm   345 -----------------------C-------IRARHSLSTGAVLR--PLLHKYT----LDPQVTR 373

  Fly   426 LHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNERSSASDRAFAEAIREKF 490
            :               :|...||:|||...:.:.:::     .|.....:..|||..|    .|.
Worm   374 I---------------VLNGSLEQVKRSCAVGQVSQK-----CLTVMSEAQYSDRVNA----GKV 414

  Fly   491 ALDEDNDQDILDQHVSRVWKDQT-PHRSPGTMSPCP-PIPSRRRTATHDSGMVSDGAMSLSGHSM 553
            :|...:  .||.|..|.:::... |....|.:|.|. |..|.|....|   :..||..  :.|..
Worm   415 SLPPRD--PILSQLPSTIYEQNNFPFHQNGDISYCEIPNESERNKHAH---LQHDGPN--AAHQQ 472

  Fly   554 KH-----------------SKSMPDHSS---------------------CSRKL--TNKWPSMN- 577
            |.                 |||.|:.|:                     .||..  ||...|.|
Worm   473 KEYTLSIFNKFVRKASHAVSKSDPNPSAGTSQDRMASGVYSPATGGPSFASRAAAGTNFGGSANQ 537

  Fly   578 TDSGISMFSADTVTK--------YKDASSRSGSSTASKLEEAKRRLEDEPRRS------------ 622
            .::|.:..|::.|::        :|..:.:......|:.|:.|.|.:|.|..|
Worm   538 VNAGSASTSSNNVSEPSKNRLSIFKSKTEKKVVKPESEKEKLKPRSDDIPTTSTSTPMAVETKPN 602

  Fly   623 -RRYAQPPMQHL-------SQQPL----------------------ASFSSSSSGGSISLPHQPP 657
             .|..:.|::.:       ||:|.                      ||.|:|:...|.|:..:..
Worm   603 GSRTTEEPLKRMGKSGDDGSQEPQGIRHPAIFSTKIGDEAAAAAAGASPSTSAPSTSTSVQTKTT 667

  Fly   658 PLPAKPPETIVV 669
            ..|.|.|.:..:
Worm   668 TSPTKSPTSTTI 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	26/120 (22%)
		Axin_b-cat_bind	494..543	CDD:285982	12/50 (24%)
		DIX	665..739	CDD:279160	0/5 (0%)
rgs-6	NP_001294820.1	RGS	47..157	CDD:214613	25/119 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810