DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axn and Axin2

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_056547.3	Gene:	Axin2 / 12006	MGIID:	1270862	Length:	840	Species:	Mus musculus

Alignment Length:	958	Identity:	215/958 - (22%)
Similarity:	339/958 - (35%)	Gaps:	347/958 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSGIRKHDDNECSGPRPPVPGEE----------------------SRVKKMTEGVADTSKNSSPS 47
            ||...:.|     .|||||||||                      |..::..:|:.:....:||.
Mouse    13 PSSSFRED-----APRPPVPGEEGETPPCQPSVGKVQSTKPMPVSSNARRNEDGLGEPEGRASPD 72

  Fly    48 --YLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQT-DPEKIKQIIGAIY 109
              ...|.::|:.||.|:||..||:.::|.|...  |.|:|:|||.|.:|.. ...|..::..|||
Mouse    73 SPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCV--DTLDFWFACNGFRQMNLKDTKTLRVAKAIY 135

  Fly   110 RFLRKSQLSISDDLRAQIK-----AIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYI 169
            :...::...:|..|:...|     .||..   .:...:||..|..::..:.:|.|..||.|::|:
Mouse   136 KRYIENNSVVSKQLKPATKTYIRDGIKKQ---QIGSVMFDQAQTEIQAVMEENAYQVFLTSDIYL 197

  Fly   170 LYIQQMSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPV 234
            .|::           ||  |..:|..|..|..||...|...||....::
Mouse   198 EYVR-----------SG--GENTAYMSNGGLGSLKVLCGYLPTLNEEEE---------------- 233

  Fly   235 SSVSGPPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEG 299
                    .||:.......|:....||.::.||.::..:.|                     .|.
Mouse   234 --------WTCADLKCKLSPTVVGLSSKTLRATASVRSTET---------------------AEN 269

  Fly   300 GGSLGSGSVGAGARAPDYPIRLTRDLLIATQKRRLEIRP--PGAHGYVYNPSTTNTSYVPNSRVD 362
            |                          ..:.||...:.|  .|: |||:.|:|        |..|
Mouse   270 G--------------------------FRSFKRSDPVNPYHVGS-GYVFAPAT--------SAND 299

  Fly   363 SERASVSSGGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSAMANKETNTFQVIPRTQRLH 427
            ||   :||...|| |:||::..|:||.|..:........:.:.:|..||.:. :....|||.||
Mouse   300 SE---LSSDALTD-DSMSMTDSSVDGVPPYRMGSKKQLQREMHRSVKANGQV-SLPHFPRTHRL- 358

  Fly   428 SNEHRPLKEEELVSLLIPKLE----EVKRKRDLEERARERNPGAALLTNERSSASDRAFAE---- 484
            ..|..|::.....:.||.:||    |::.:..||||.::      :..:|....|::|.:.
Mouse   359 PKEMTPVEPAAFAAELISRLEKLKLELESRHSLEERLQQ------IREDEEKEGSEQALSSRDGA 417

  Fly   485 AIREKFAL-----DEDNDQDILDQHVSRVWKD---QTP--------HRSP--------------- 518
            .::...||     .|::.|.|||.|:|||.|.   |:|        .|||
Mouse   418 PVQHPLALLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHQHHHHQQCHTL 482

  Fly   519 ----GTMSP-------------------------------------------------CP----- 525
                |.:.|                                                 ||
Mouse   483 LPTGGKLPPVAACPLLGGKSFLTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDY 547

  Fly   526 --------------PIP------SRRRT---------------ATHDSGMVS-DGAMSLSG---- 550
                          |:|      ||..|               :..|.||.| .||..|.|
Mouse   548 YCYSKCKSHPKAPEPLPGEQFCGSRGGTLPKRNAKGTEPGLALSARDGGMSSAAGAPQLPGEEGD 612

  Fly   551 ----------HSMKHSKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTKYK--DASSRSGS- 602
                      .|.:.|||.|..:...||      |...:|..:. ..:.|:::.  .||..|.|
Mouse   613 RSQDVWQWMLESERQSKSKPHSAQSIRK------SYPLESACAA-PGERVSRHHLLGASGHSRSV 670

  Fly   603 ------------------STASKLEEAKRRLED--EPRRSRRYAQPPMQHLSQQPLASFSSSSSG 647
                              :|.::||||.|||.:  :|::.|...      .|||...:.|::...
Mouse   671 ARAHPFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCCV------ASQQRDRNHSAAGQA 729

  Fly   648 GSISLPHQPPPL-------PAK--------PPETIVVFSFCEEPVPYRIKIPGTQPTLRQFKDYL 697
            |  :.|...|.|       |.|        ..|.:|.:.||.|.:|||..:.....||..||:.|
Mouse   730 G--ASPFANPSLAPEDHKEPKKLASVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQL 792

  Fly   698 PRRGHFRFFFKTHCEDPDSPVIQEEIVNDSDILPLFGDKAMGLVKPSD 745
            .::|::|::||...::.....:.|||.:|..:||::..:.:|.|:..|
Mouse   793 SKKGNYRYYFKKASDEFACGAVFEEIWDDETVLPMYEGRILGKVERID 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	36/120 (30%)
		Axin_b-cat_bind	494..543	CDD:285982	28/168 (17%)
		DIX	665..739	CDD:279160	23/73 (32%)
Axin2	NP_056547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		16/66 (24%)
		AXIN1_TNKS_BD	10..73	CDD:374700	16/64 (25%)
		Tankyrase-binding motif	21..30		7/8 (88%)
		RGS_Axin	82..198	CDD:188662	36/120 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..363		22/68 (32%)
		Interaction with GSK3B. /evidence=ECO:0000250	327..413		22/93 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..435		6/36 (17%)
		Interaction with beta-catenin. /evidence=ECO:0000250	413..478		17/64 (27%)
		Axin_b-cat_bind	432..467	CDD:370146	13/34 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..485		6/37 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	572..614		10/41 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..745		8/31 (26%)
		DAX	758..840	CDD:197474	25/81 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9589
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I4087
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50119
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003472
OrthoInspector	1	1.000	-	-		otm43541
orthoMCL	1	0.900	-	-		OOG6_105312
Panther	1	1.100	-	-	LDO	PTHR46102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4975
SonicParanoid	1	1.000	-	-		X2363
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860