Protein Alignment Axn and Axin1

DIOPT Version :9

• Sequence 1: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_001381310.1
• Gene: Axin1 / 12005
• MGIID: 1096327
• Length: 863
• Species: Mus musculus
• Alignment Length: 971
• Identity: 231/971 - (23%)
• Similarity: 355/971 - (36%)
• Gaps: 372/971 - (38%)

  Fly    19 PRPPVPGEE--------------------SRVKKMTEGVA------------DTSKNSSPSYLNW 51
            |||||||||                    :.:|..|....            :.|.:.:|.||.|
Mouse    21 PRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPYLRW 85

  Fly    52 ARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQ----QTDPEKIKQIIGAIYR-F 111
            |.:|:.||:|:||:.||:.::::|..|  |.|:|:|||.|.::    .::.||..::..|||| :
Mouse    86 AESLHSLLDDQDGISLFRTFLKQEGCA--DLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKY 148

  Fly   112 LRKSQLSISDDLRAQIKAIKTN--PEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQ 174
            :..|...:|...:...|:...:  .:..:.|.:||..|..::.|:.:|.||:||.|::|:.|.:.
Mouse   149 ILDSNGIVSRQTKPATKSFIKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRT 213

  Fly   175 MSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSG 239
            .|...:.|:..         |||||             |..|
Mouse   214 GSESPKVCSDQ---------SSGSG-------------TGKG----------------------- 233

  Fly   240 PPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLG 304
                                            .|..||||:||.... ||.    ...|..|
Mouse   234 --------------------------------MSGYLPTLNEDEEWK-CDQ----DADEDDG--- 258

  Fly   305 SGSVGAGARAPDYPIRLTRDLLIATQKRRL----------EIRPPGAHGYVYNPSTTNTSYV--- 356
                    |.|..|.|||:.||:.|...|.          |:| .|:.....||...|:.|.
Mouse   259 --------RDPLPPSRLTQKLLLETAAPRAPSSRRYNEGRELR-YGSWREPVNPYYVNSGYALAP 314

  Fly   357 PNSRVDSERASVSSGGRTDSDTMSISSCSMDG-RPY-IQRRHSSTESKAIRQSAMANKETNTFQV 419
            ..|..|||:.|:||    |:||:|::..|:|| .|| |:::|    .:.:::|...|... ....
Mouse   315 ATSANDSEQQSLSS----DADTLSLTDSSVDGIPPYRIRKQH----RREMQESIQVNGRV-PLPH 370

  Fly   420 IPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARER--------------NPGAALL 470
            ||||.|: ..|.| ::.::....||.:||.|:|.|:.||:..||              .|...:.
Mouse   371 IPRTYRM-PKEIR-VEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGEMPSGPMA 433

  Fly   471 TNERSSAS----------DRAFAEAIREKFALDEDNDQDILDQHVSRVWKD---QTP---HRSP- 518
            :::..|..          |.. ...:|:   ..|:|.:.|||:||.||.:.   |:|   ||||
Mouse   434 SHKLPSVPAWHHFPPRYVDMG-CSGLRD---AHEENPESILDEHVQRVMRTPGCQSPGPGHRSPD 494

  Fly   519 -----------GTMS----PCPPI----------------------------------------- 527
                       ||.|    ..|.:
Mouse   495 SGHVAKTAVLGGTASGHGKHVPKLGLKLDTAGLHHHRHVHHHVHHNSARPKEQMEAEVARRVQSS 559

  Fly   528 -------------------------------------PSRRRTATHDSG---------------- 539
                                                 ||:|.|...:||
Mouse   560 FSWGPETHGHAKPRSYSENAGTTLSAGDLAFGGKTSAPSKRNTKKAESGKNANAEVPSTTEDAEK 624

  Fly   540 ------MVSDGAMSLS-----GHSMKHSKSMPDHSSCSRKLT-------NKWPSMNTDSGIS--- 583
                  .:.:|...:|     ||.....:....|.| ||.|:       :.|.|....:.:.
Mouse   625 NQKIMQWIIEGEKEISRHRKAGHGSSGLRKQQAHES-SRPLSIERPGAVHPWVSAQLRNSVQPSH 688

  Fly   584 MFSADTVTKYKDASSRSGSSTASKLEEAKRRLEDEPRRS------RRYAQPPMQH---------- 632
            :|..|.......|     .:..::||||:||||:|.:|:      :||.|..||.
Mouse   689 LFIQDPTMPPNPA-----PNPLTQLEEARRRLEEEEKRANKLPSKQRYVQAVMQRGRTCVRPACA 748

  Fly   633 --LSQQPLAS----------FSSSSSGGSISLPHQPPPLPAKPPETIVV-FSFCEEPVPYRIKIP 684
              ||..|..|          ....:.|||           |.|.::||| :.||.||:|||..:.
Mouse   749 PVLSVVPAVSDLELSETETKSQRKAGGGS-----------APPCDSIVVAYYFCGEPIPYRTLVR 802

  Fly   685 GTQPTLRQFKDYLPRRGHFRFFFKTHCEDPDSPVIQEEIVNDSDILPLFGDKAMGLVKPSD 745
            |...||.|||:.|.::|.:|::||...::.|..|:.||:..|..:||:|.:|.:|.|:..|
Mouse   803 GRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	38/121 (31%)
		Axin_b-cat_bind	494..543	CDD:285982	25/170 (15%)
		DIX	665..739	CDD:279160	30/74 (41%)
Axin1	NP_001381310.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..81		12/59 (20%)
		Axin_TNKS_binding	11..80	CDD:211424	12/58 (21%)
		Tankyrase-binding motif	20..29		7/7 (100%)
		RGS_Axin	89..209	CDD:188662	38/121 (31%)
		Interaction with TP53. /evidence=ECO:0000269|PubMed:15526030	209..338		49/226 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..240		11/101 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..268		8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..344		14/32 (44%)
		Interaction with GSK3B. /evidence=ECO:0000250	348..432		23/90 (26%)
		Interaction with beta-catenin. /evidence=ECO:0000250	433..501		18/71 (25%)
		Axin_b-cat_bind	464..495	CDD:400956	14/30 (47%)
		Interaction with RNF111. /evidence=ECO:0000250	505..758		42/258 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..624		6/94 (6%)
		Interaction with PPP2CA. /evidence=ECO:0000250	572..790		47/234 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..664		6/22 (27%)
		Interaction with HIPK2. /evidence=ECO:0000269|PubMed:15526030	678..753		19/79 (24%)
		DIX	783..860	CDD:395628	31/76 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9589
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I4087
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50119
OrthoDB	1	1.010	-	-		D1481971at2759
OrthoFinder	1	1.000	-	-		FOG0003472
OrthoInspector	1	1.000	-	-		otm43541
orthoMCL	1	0.900	-	-		OOG6_105312
Panther	1	1.100	-	-	O	PTHR46102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4975
SonicParanoid	1	1.000	-	-		X2363
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870