DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axn and RGS14

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_024310096.1	Gene:	RGS14 / 10636	HGNCID:	9996	Length:	593	Species:	Homo sapiens

Alignment Length:	660	Identity:	145/660 - (21%)
Similarity:	238/660 - (36%)	Gaps:	180/660 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGPRPPVPGEESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYND 81
            |||..|.|.||..|                  .:||.:...||:|..|:..|.:::::|..|.|
Human    48 SGPSSPFPTEEQPV------------------ASWALSFERLLQDPLGLAYFTEFLKKEFSAEN- 93

  Fly    82 HLNFYFACEGLKQ--QTDPEKIKQIIGAIYR-FLRKSQLS-ISDDLRAQI-KAIKTNPEIPLSPH 141
             :.|:.|||..:|  .:|.:::.|....||: ||....|| ::.|.:|.: :.:...|.    |.
Human    94 -VTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQALSPVNIDRQAWLGEEVLAEPR----PD 153

  Fly   142 IFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTSSGATGS--GSAGSSGSGGSSLA 204
            :|...|..:...::.:.|..|:.|.:|           ..|..:.|.|.  ...|||..|...
Human   154 MFRAQQLQIFNLMKFDSYARFVKSPLY-----------RECLLAEAEGRPLREPGSSRLGSPD-- 205

  Fly   205 GACALPPTTASGK------QQLPQLVPPGAFINLPVSSVSGPPAGTCSAS-----GSVYGPSTSA 258
             |....|....||      ::|.||.|           |.||.......|     |.....:...
Human   206 -ATRKKPKLKPGKSLPLGVEELGQLPP-----------VEGPGGRPLRKSFRRELGGTANAALRR 258

  Fly   259 SSSGSISATDTLPRS-----STLPTLHEDSVLSLCDDFEK-------VQMQEGGGSLGSGSVGAG 311
            .|.||::::.:|...     |:....|..|:.|...:.|.       |.:.:|..||.....|
Human   259 ESQGSLNSSASLDLGFLAFVSSKSESHRKSLGSTEGESESRPGKYCCVYLPDGTASLALARPG-- 321

  Fly   312 ARAPDYPIRLT-RDLLIA-TQKRRLEIRPPGAHGYVYNPSTTNTSYVPNSRV----DSERASVSS 370
                     || ||:|.. .:||.|.:                    |:.:|    :.::|.|..
Human   322 ---------LTIRDMLAGICEKRGLSL--------------------PDIKVYLVGNEQKALVLD 357

  Fly   371 GGRTDSDTMSISSCSMDGRPYIQRRHSSTESKAIRQSAMANKETNTFQ-----------VIPRTQ 424
               .|...::.....::.|...:...::.| :.:|.||   |.|...|           :.|...
Human   358 ---QDCTVLADQEVRLENRITFELELTALE-RVVRISA---KPTKRLQEALQPILEKHGLSPLEV 415

  Fly   425 RLH-SNEHRPLKEEELVS------LLIPKLEEVKRKRDLEERARERNPGAALLTNERSSASDRAF 482
            .|| ..|.:||...:|||      |::..|..||     ..:||:::|..:.::..|.::|...|
Human   416 VLHRPGEKQPLDLGKLVSSVAAQRLVLDTLPGVK-----ISKARDKSPCRSQVSERRVASSTLCF 475

  Fly   483 AEAIREKFALDEDNDQDILDQHVSRVWKDQTPHRSPGTMSPCPPIPS----RRRTATHDSGMV-- 541
            :.   ..|..|....|....:     .:|:..|..|.:.|....:||    :|:|...: |:|
Human   476 SP---PDFGSDPKFSQGCPPR-----TQDKATHPPPASPSSLVKVPSSATGKRQTCDIE-GLVEL 531

  Fly   542 -----SDGAMSLSGHSMKHSKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTKYKDASSRSG 601
                 |.||....|...|....:|:.    .:|..:.||          |.:|..:.|.|:...|
Human   532 LNRVQSSGAHDQRGLLRKEDLVLPEF----LQLPAQGPS----------SEETPPQTKSAAQPIG 582

  Fly   602 SSTASKLEEA 611
            .|..|..:.|
Human   583 GSLNSTTDSA 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	31/119 (26%)
		Axin_b-cat_bind	494..543	CDD:285982	11/59 (19%)
		DIX	665..739	CDD:279160
RGS14	XP_024310096.1	RGS_RGS14	58..186	CDD:188697	36/162 (22%)
		RGS12_us1	189..273	CDD:318754	22/97 (23%)
		RGS12_RBD	303..376	CDD:176412	19/106 (18%)
		RBD	376..445	CDD:128731	17/72 (24%)
		GoLoco	525..547	CDD:214645	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810