DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Axn and RGS19

DIOPT Version :9

Sequence 1:NP_733336.1 Gene:Axn / 43565 FlyBaseID:FBgn0026597 Length:745 Species:Drosophila melanogaster
Sequence 2:XP_011526786.1 Gene:RGS19 / 10287 HGNCID:13735 Length:246 Species:Homo sapiens


Alignment Length:158 Identity:37/158 - (23%)
Similarity:70/158 - (44%) Gaps:15/158 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 ESRVKKMTEGVADTSKNSSPSYL-NWARTLNHLLEDRDGVELFKKYVEEEAPAYN-DHLNFYFAC 89
            ||:::.:..  .:.....||..: :||::.:.|:....|..:|:.::..|   |: :::.|:.||
Human    93 ESKLQPLPS--CEVCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTE---YSEENMLFWLAC 152

  Fly    90 EGLKQQTDPEKIKQIIGAIYR----FLRKSQLSISDDLRAQIKAIKTNPEIPLSPHIFDPMQRHV 150
            |.||.:.:...:.:....||.    .|...::|:...:|..|......|    |.|.||..|..:
Human   153 EELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEP----SAHTFDDAQLQI 213

  Fly   151 EVTIRDNIYPTFLCSEMYILYIQQMSAQ 178
            ...:..:.||.||.|..|...:.|..:|
Human   214 YTLMHRDSYPRFLSSPTYRALLLQGPSQ 241

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AxnNP_733336.1 RGS 55..170 CDD:295367 29/119 (24%)
Axin_b-cat_bind 494..543 CDD:285982
DIX 665..739 CDD:279160
RGS19XP_011526786.1 RGS_RGS19 116..233 CDD:188699 31/123 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3589
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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