DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axn and axin1

DIOPT Version :9

Sequence 1:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_002935881.2	Gene:	axin1 / 100498631	XenbaseID:	XB-GENE-486781	Length:	877	Species:	Xenopus tropicalis

Alignment Length:	977	Identity:	231/977 - (23%)
Similarity:	361/977 - (36%)	Gaps:	370/977 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PRPPVPGEESR--------------------VKKMTEGVA------------DTSKNSSPSYLNW 51
            |||||||||..                    :|..|....            :.|.:.:|.||.|
Frog    21 PRPPVPGEEGELITTDQRPFSHSYYSLKNDGIKNETSTATPRRPDLDLGYEPEGSASPTPPYLKW 85

  Fly    52 ARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQ----QTDPEKIKQIIGAIY-RF 111
            |.:|:.||:|:||:.||:.::::|..|  |.|:|:|||.|.::    .:..||..::..||| ::
Frog    86 AESLHSLLDDQDGINLFRTFLQQENCA--DLLDFWFACSGFRKLEPNDSKVEKRLKLAKAIYKKY 148

  Fly   112 LRKSQLSISDDLRAQIKAIKTNPEI--PLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQ 174
            :..|...:|..::...|:...:..:  .:.|.:||..|..::..:.||.||.||.|:.|:.|
Frog   149 ILDSNGIVSRQIKPATKSFIKDCVLRQQIDPAMFDQAQTEIQSMMEDNTYPVFLKSDTYLEY--- 210

  Fly   175 MSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSG 239
                                 :..||.|        |...|.:.
Frog   211 ---------------------TTIGGES--------PKNYSDQS--------------------- 225

  Fly   240 PPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLG 304
                  ||||:..||                  |..||||:||.... ||.         ||.|
Frog   226 ------SASGTGKGP------------------SGYLPTLNEDEEWR-CDQ---------GGEL- 255

  Fly   305 SGSVGAGARAPD-YPIRL-TRDLLIATQ------KRRL----EIRPPGAHGYVYNPSTTNTSYV- 356
                   .|..| .|..| |:.|::.:.      .|||    |.| ||......||...||.|.
Frog   256 -------ERERDSVPSSLFTQKLVLDSSSHCVGPNRRLSDGREFR-PGTWREPVNPYYVNTGYAV 312

  Fly   357 --PNSRVDSERASVSSGGRTDSDTMSISSCSMDG-RPYIQRRHSSTESKAIRQSAMANKETNTFQ 418
              ..|..|||:.|:||    |:||||::..|:|| .||..|:|...|   :::||.||.. ....
Frog   313 APVTSANDSEQQSMSS----DADTMSLTDSSVDGIPPYRLRKHYRRE---MQESANANGR-GPLP 369

  Fly   419 VIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARER---------------NPGAA 468
            .||||..:..:.|  :..|:..:.||.:||.|.|.|:.|::..||               :.|.:
Frog   370 HIPRTYHMPKDIH--VDPEKFAAELISRLEGVLRDREAEQKLEERLKRVRAEEEGDDGDVSSGPS 432

  Fly   469 LLTNE----------RSSASDR-AFAEAIREKFALDEDNDQDILDQHVSRVWKDQTPH-RSPGT- 520
            :::::          .|..||. .....:|:   ..|:|.:.|||:||.||.|  ||. :||||
Frog   433 IISHKLPSGPPMHHYNSRYSDMGCVGMQVRD---AHEENPESILDEHVQRVMK--TPGCQSPGTG 492

  Fly   521 -MSPCPPIPSRRRTAT-----------HDSGMVSDGAMSLSGHSMKHSKSMPDH----------- 562
             .||.|..|....:.|           |.......|:...|| :|.|.|.:..|
Frog   493 RHSPKPRSPDGHVSKTLPGSLGTMQTGHGKHTSKSGSKVDSG-NMHHHKHVYHHVHHHGGVKPKE 556

  Fly   563 ---SSCSRKLTNKWP---------------------------SMNTDSGISMFS------AD--- 588
               :..::::...:|                           |:.....:||.|      ||
Frog   557 QIEAEATQRVQTNFPWNVESHNYATKSRNYAESMGMAPNPMDSLAYSGKVSMLSKRNAKKADLGK 621

  Fly   589 ------------------------------TVTKYKDAS-SRSGS-------------------- 602
                                          .::::|.:: |.||:
Frog   622 SESASYEMPVVPEDAERHQKILQWIMEGEKEISRHKKSNHSSSGAKKQPPSELPRPLSIERPGAV 686

  Fly   603 ------------------------------STASKLEEAKRRLEDEPRRS------RRYAQPPMQ 631
                                          :..::||||:||||:|.:|:      :||.|..:|
Frog   687 HPWVSAQLRNVVQPSHPFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRAGKMPQKQRYVQEVIQ 751

  Fly   632 H------------------LSQQPLASFSSSSSGGSISLPHQPPPLPAKPPETIVVFSFCEEPVP 678
            .                  :|...|:.....:...|:.:|.|      .....:|.:.||.||:|
Frog   752 RGRCPARPAYVPLLNVVPAVSDMDLSEAELKAQKKSVGVPSQ------LCDNIVVAYYFCGEPIP 810

  Fly   679 YRIKIPGTQPTLRQFKDYLPRRGHFRFFFKTHCEDPDSPVIQEEIVNDSDILPLFGDKAMGLVKP 743
            ||..:.|...||.|||:.|.::|::|::||...::.|..|:.||:..|..|||::.:|.:|.|:.
Frog   811 YRTMVKGRVVTLGQFKELLTKKGNYRYYFKKVSDEFDCGVVFEEVREDDMILPIYEEKIIGKVEK 875

  Fly   744 SD 745
            .|
Frog   876 ID 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axn	NP_733336.1	RGS	55..170	CDD:295367	37/121 (31%)
		Axin_b-cat_bind	494..543	CDD:285982	22/62 (35%)
		DIX	665..739	CDD:279160	28/73 (38%)
axin1	XP_002935881.2	Axin_TNKS_binding	11..80	CDD:211424	12/58 (21%)
		RGS_Axin	89..209	CDD:188662	37/121 (31%)
		Axin_b-cat_bind	467..503	CDD:400956	19/37 (51%)
		DIX	797..874	CDD:395628	29/76 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3730
OMA	1	1.010	-	-		QHG50119
OrthoDB	1	1.010	-	-		D1481971at2759
OrthoFinder	1	1.000	-	-		FOG0003472
OrthoInspector	1	1.000	-	-		otm48700
Panther	1	1.100	-	-	O	PTHR46102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4975
SonicParanoid	1	1.000	-	-		X2363
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110