DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mgat2 and MGAT2

DIOPT Version :9

Sequence 1:	NP_651763.4	Gene:	Mgat2 / 43563	FlyBaseID:	FBgn0039738	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_002399.1	Gene:	MGAT2 / 4247	HGNCID:	7045	Length:	447	Species:	Homo sapiens

Alignment Length:	521	Identity:	176/521 - (33%)
Similarity:	256/521 - (49%)	Gaps:	136/521 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 ASGAGALNG--AALLLNASSPGAATASTISFDVYHP--PNITEIKRQIV-RYNDMQMVLNEDVFG 148
            |.|||...|  .::.:........:|:::...|..|  .|:|...|.:| :.|..|.:.|.|..|
Human    47 ARGAGGRGGDHPSVAVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAG 111

  Fly   149 PLQNDSVIIVVQVHTRITYLRHLIVSLAQARDISKVLLVFSHDYYDDDINDLVQQIDFCKVMQIF 213
            ......:::|||||.|..|||.|:.||.:|:.|..||::||||::..:||.|:..::||.|:|:|
Human   112 TWAPRELVLVVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVF 176

  Fly   214 YPYSIQTHPNEYPGVDPNDCPRNIKKEQALITNCNNAMYPDLYGHYREAKFTQTKHHWIWKANRV 278
            :|:|||.:|||:||.||.||||::.|..||...|.||.|||.:||||||||:||||||.||.:.|
Human   177 FPFSIQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFV 241

  Fly   279 FNELEVTRYHTGLVLFLEEDHYVAEDFLYLLAMMQQRTKDLCPQCNVLSLGTYLKTFNYYTYHSK 343
            :..:::.|.:.||:||||||||:|.||.::...|.:..:..||:|:|||||||
Human   242 WERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTY------------ 294

  Fly   344 TNKKSYASSLISTNSLLGYNRNNNRNSVQLAVSSSYSSSSSAQSPPPSKVYVGDTSDNQRASDSS 408
                                                                           |:
Human   295 ---------------------------------------------------------------SA 296

  Fly   409 SRRGNLINTVTDTATATAATSDTSNNEQSSHSSSKNGAQTWNYHVLPSLYSVYQKVEVMPWVSSK 473
            ||                                             |.|.:..||:|..|.|::
Human   297 SR---------------------------------------------SFYGMADKVDVKTWKSTE 316

  Fly   474 HNMGFAFNRTTWSNIRKCARHFCTYDDYNWDWSLQHVSQQCLRRKLHAMIVKGPRVFHIGECGVH 538
            ||||.|..|..:..:.:|...|||||||||||:||:::..||.:....::.:.||:||.|:||:|
Human   317 HNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPKFWKVLVPQIPRIFHAGDCGMH 381

  Fly   539 HKNKNCESNQVISKVQHVLRIARNSHQLFPRSLTL----TVPSLMKKSKLRKGNGGWGDMRDHEL 599
            || |.|..:...::::.:|.  .|...:||.:||:    ||.::....|    ||||||:|||||
Human   382 HK-KTCRPSTQSAQIESLLN--NNKQYMFPETLTISEKFTVVAISPPRK----NGGWGDIRDHEL 439

  Fly   600 C 600
            |
Human   440 C 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mgat2	NP_651763.4	MGAT2	129..600	CDD:282863	164/475 (35%)
MGAT2	NP_002399.1	MGAT2	92..440	CDD:282863	164/474 (35%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:29666272, ECO:0007744\|PDB:5VCM	123..127		3/3 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:29666272, ECO:0007744\|PDB:5VCM	229..233		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156935
Domainoid	1	1.000	226	1.000	Domainoid score	I2526
eggNOG	1	0.900	-	-		E1_KOG2791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1806
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249424at33208
OrthoFinder	1	1.000	-	-		FOG0004842
OrthoInspector	1	1.000	-	-		oto89742
orthoMCL	1	0.900	-	-		OOG6_106024
Panther	1	1.100	-	-	LDO	PTHR12871
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3486
SonicParanoid	1	1.000	-	-		X3420
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.740