DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7920 and ACH1

DIOPT Version :9

Sequence 1:	NP_001263095.1	Gene:	CG7920 / 43562	FlyBaseID:	FBgn0039737	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_009538.1	Gene:	ACH1 / 852266	SGDID:	S000000111	Length:	526	Species:	Saccharomyces cerevisiae

Alignment Length:	526	Identity:	116/526 - (22%)
Similarity:	192/526 - (36%)	Gaps:	155/526 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LSHPIAREPPIVKPEEA---VACVKSGDTV----FAGGAAATPVALLNAMAKHGKSNNLECVTVC 95
            |...:...|.:.|.:||   :...|:|..:    |.|  ..||.|:..|:..|.:.|||:.....
Yeast     7 LKQRVRYAPYLKKVKEAHELIPLFKNGQYLGWSGFTG--VGTPKAVPEALIDHVEKNNLQGKLRF 69

  Fly    96 HMH---TEGPGEYAKPEYKDHFRSNSFFMGANVRKAVADGR----GDNVPIFLHEIPNLFY---- 149
            ::.   :.||.|....|:....:.....:|..:.||:..||    ..::.:|..::...||
Yeast    70 NLFVGASAGPEENRWAEHDMIIKRAPHQVGKPIAKAINQGRIEFFDKHLSMFPQDLTYGFYTRER 134

  Fly   150 ---------------------------------------KQIVK-----PDVSFIH-----VSPP 165
                                                   |.|::     |....||     |:||
Yeast   135 KDNKILDYTIIEATAIKEDGSIVPGPSVGGSPEFITVSDKVIIEVNTATPSFEGIHDIDMPVNPP 199

  Fly   166 DNHGYCSLGTSVDC-VRAALLNSKLIVA--------QINPKMPRTFGDAIIHKSHFDLAIEVTDD 221
            ....|..|.....| |.:..::.:.:||        |:.|..|                   :||
Yeast   200 FRKPYPYLKVDDKCGVDSIPVDPEKVVAIVESTMRDQVPPNTP-------------------SDD 245

  Fly   222 LPQHGTGKISEV---EKKIGKLIAENLVKDGATLQMGIGSIPDAVLAAL--HNHKDLGIHSEMFA 281
            :.:...|.:.|.   |.|.|:| .|||:    .||.|||:|.:||:..|  ...|.|.:.:|:..
Yeast   246 MSRAIAGHLVEFFRNEVKHGRL-PENLL----PLQSGIGNIANAVIEGLAGAQFKHLTVWTEVLQ 305

  Fly   282 NGVVELVRKG----CVTNSKKKMHQGRIVGSFLIGDKALYDF-------------VDNNPFIEMY 329
            :..::|...|    ....|.:...:|        .|:|..::             |.|||
Yeast   306 DSFLDLFENGSLDYATATSVRLTEKG--------FDRAFANWENFKHRLCLRSQVVSNNP----- 357

  Fly   330 AIDYVNNTSIVKQQPRMTAINSCIEVDLTGQVCSDSI-GPRFYSGFGGQVDFIRGAAEGLDGLGV 393
              :.:....::       |:|:.:|||:.....|.:: |.|..:|.||..||:|.|.  |..:..
Yeast   358 --EMIRRLGVI-------AMNTPVEVDIYAHANSTNVNGSRMLNGLGGSADFLRNAK--LSIMHA 411

  Fly   394 PIIAMPSTTNKGESKIVPTLKEGAGVVTSRAH-VHYVVTEHGIASLFGKNVRQRMYELI-QIADP 456
            |..........|.|.|||.    |..|....| :..:||:.|:|.|.|.:.::|..|:| :.|.|
Yeast   412 PSARPTKVDPTGISTIVPM----ASHVDQTEHDLDILVTDQGLADLRGLSPKERAREIINKCAHP 472

  Fly   457 KHRETL 462
            .::..|
Yeast   473 DYQALL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7920	NP_001263095.1	ACH1	43..466	CDD:223504	115/521 (22%)
		SugarP_isomerase	51..217	CDD:294243	43/241 (18%)
		AcetylCoA_hyd_C	312..466	CDD:290075	43/167 (26%)
ACH1	NP_009538.1	ACH1	6..519	CDD:223504	116/526 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346280
Domainoid	1	1.000	44	1.000	Domainoid score	I3149
eggNOG	1	0.900	-	-		E1_COG0427
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1.056642	Normalized mean entropy	S12194
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto100310
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16219
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.680