DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7920 and SPAC1952.09c

DIOPT Version :9

Sequence 1:	NP_001263095.1	Gene:	CG7920 / 43562	FlyBaseID:	FBgn0039737	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_594811.1	Gene:	SPAC1952.09c / 2542515	PomBaseID:	SPAC1952.09c	Length:	521	Species:	Schizosaccharomyces pombe

Alignment Length:	520	Identity:	110/520 - (21%)
Similarity:	194/520 - (37%)	Gaps:	162/520 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 IVKPEEAVACVKSGDTV----FAGGAAATPVALLNAMAKHGKSNNLE--------------CVTV 94
            :..|.:.|...|:||.|    |.|  ...|..:.||:|:|.:.|||:              ..|.
pombe    19 VTDPAKLVPYFKNGDYVGWSGFTG--VGYPKMIPNALARHVEENNLQGKLRFKLFVGASGGADTE 81

  Fly    95 CH------MHTEGPGEYAKPEYKDHFRSNSFFMGANVRKAVADGR----GDNVPIFLHEIPNLFY 149
            |.      :....|.:..||                :.|.:..||    ..::.:|..::...:|
pombe    82 CKWAELNMIERRCPHQVGKP----------------ISKGINSGRIQFFDKHLSMFPQDLLYGYY 130

  Fly   150 ---KQIVKPDVSFIHVSPPDNHGYCSLGTSVDCVRAALLNSKLIVAQINPKMPRTFGDAIIHKSH 211
               ::....|.:.|..:.....|....|.||......:..::.|:.::|..:|...|   :|
pombe   131 TRNRESNTIDTAIIEATAITEDGGIVPGASVGASPELMQLAEKIIIEVNTAIPSFEG---LH--- 189

  Fly   212 FDLAIEVTDDLPQHGTG-KISEVEKKIGK---------------------------------LIA 242
             |: :|:.:  |.|.|. .|:.|:.:|||                                 .||
pombe   190 -DI-VEIPN--PPHRTPININRVDDRIGKPYIKVDPKKVIGIVEADYGDITCANSPQDETSQAIA 250

  Fly   243 ENLV-------------KDGATLQMGIGSIPDAVLAAL-HN-HKDLGIHSEMFANGVV-----EL 287
            .:||             |:...||.|||:|.:|::..| |: .|||.:.:|:..:..:     |.
pombe   251 GHLVDFFHHEVSVGRLPKNLHPLQSGIGNIANAIIGGLAHSPFKDLEVWTEVLQDTFLPLFDSEK 315

  Fly   288 VRKGCVTNSK------KKMHQGRIVGSFLIGDKALYDFVDNNPFIEMYAIDYVNNTSIVKQQPRM 346
            :|....|:::      :|.:..             ||:......:....|.  |:..|:::. ..
pombe   316 LRFATATSTRFSPQGFEKFYSN-------------YDYYKERILLRPQVIS--NHPEIIRRL-GC 364

  Fly   347 TAINSCIEVDLTGQVCSDSI-GPRFYSGFGGQVDFIRGAAEGLDGLGVPIIAMPSTTNKGESKIV 410
            .|:|:.:|.|:.....|.:: |.|..:|.||..||:|.|.       :.|:..||        :.
pombe   365 IAMNTPVEADIYAHANSTNVLGSRMLNGLGGSADFLRNAK-------LSIMHTPS--------VR 414

  Fly   411 PTLKEGAG---VVTSRAHV-------HYVVTEHGIASLFGKNVRQRMYELI-QIADPKHRETLEK 464
            |:.|:..|   :|....||       ..:|||.|:|.|.|.:..:|..|:| :.|.|.::..|.:
pombe   415 PSKKDPTGITCIVPMATHVDQTEHDLDILVTEQGLADLRGLSPTERAREVIDKCAHPDYKPLLRE 479

Fly 465 464
pombe 480 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7920	NP_001263095.1	ACH1	43..466	CDD:223504	110/520 (21%)
		SugarP_isomerase	51..217	CDD:294243	38/196 (19%)
		AcetylCoA_hyd_C	312..466	CDD:290075	41/165 (25%)
SPAC1952.09c	NP_594811.1	ACH1	4..518	CDD:223504	110/520 (21%)
		SugarP_isomerase	10..229	CDD:294243	47/237 (20%)
		AcetylCoA_hyd_C	330..481	CDD:290075	42/181 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	41	1.000	Domainoid score	I3713
eggNOG	1	0.900	-	-		E1_COG0427
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	47	1.000	Inparanoid score	I2076
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16219
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.850