DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlp and npm1b

DIOPT Version :9

Sequence 1:	NP_001263094.1	Gene:	Nlp / 43560	FlyBaseID:	FBgn0016685	Length:	152	Species:	Drosophila melanogaster
Sequence 2:	XP_005173145.2	Gene:	npm1b / 553507	ZFINID:	ZDB-GENE-080723-7	Length:	316	Species:	Danio rerio

Alignment Length:	205	Identity:	52/205 - (25%)
Similarity:	88/205 - (42%)	Gaps:	66/205 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YGVTLTAESDSVTWDVDEDYARGQKLVIKQILLGAEAKENEFNVVE---VNTPKDSVQIPIAVLK 68
            :|.:|.|:......|:|:|.|..| |.:|.:.||||| |::|:.||   :.....:.:|.:||||
Zfish    33 FGCSLKADKKEHKVDLDDDEAEHQ-LSLKSVCLGAEA-EDKFHTVEMEGLTYDGKTTKITLAVLK 95

  Fly    69 AGETRAVNPDVEFYESKVT----FKLIKGSGPVYIHGHNI------------------------- 104
            .    :|.|.:.....:||    |:|..|.|||||.|.:.
Zfish    96 P----SVLPSLSLGGFEVTPPVSFRLQSGGGPVYISGQHFVSVKESDDEDEEEEENNTSPVKRPS 156

  Fly   105 ---------------KDDVEVVDMEEDDEEDDVAEDEEDEHPKKRAKIEN-------------AA 141
                           .|:.|..|.::||::||..::|||:..:::..:::             :|
Zfish   157 NMTLAKVPQKKLKMDSDEDEDSDDDDDDDDDDDDDEEEDDDKQEKPAVKSPVKSTQKTPEKKKSA 221

  Fly   142 DGKNAKNNKK 151
            |.:|...:||
Zfish   222 DKQNGSPDKK 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlp	NP_001263094.1	Nucleoplasmin	6..104	CDD:397268	37/103 (36%)
npm1b	XP_005173145.2	Nucleoplasmin	32..131	CDD:308605	37/103 (36%)
npm1b	XP_005173145.2	NPM1-C	265..313	CDD:318505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594268
Domainoid	1	1.000	46	1.000	Domainoid score	I12094
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5397
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1485080at2759
OrthoFinder	1	1.000	-	-		FOG0000973
OrthoInspector	1	1.000	-	-		oto41272
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22747
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.000