DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlp and Npm2

DIOPT Version :9

Sequence 1:	NP_001263094.1	Gene:	Nlp / 43560	FlyBaseID:	FBgn0016685	Length:	152	Species:	Drosophila melanogaster
Sequence 2:	NP_851990.2	Gene:	Npm2 / 328440	MGIID:	1890811	Length:	207	Species:	Mus musculus

Alignment Length:	170	Identity:	58/170 - (34%)
Similarity:	76/170 - (44%)	Gaps:	32/170 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AEESFYGVTLTAESDSVTWDVDEDYARGQ-------KLVIKQILLGAEAKENEFNVVEVNTPKD- 58
            |:...:|..|..|..:.|:       |||       ||::..|.||.:||| |.|.|||.:.:.
Mouse    14 AKNMLWGSELNQEKQTCTF-------RGQGEKKDSCKLLLSTICLGEKAKE-EVNRVEVLSQEGR 70

  Fly    59 SVQIPIAVLKAGETRAVNPDVEFYESKVTFKLIKGSGPVYIHGHNIKDDVEVVDME-EDDEEDDV 122
            ...|.||.|||.....|..........|||:|..|||||::.|   .:..|..|:. |||||::.
Mouse    71 KPPITIATLKASVLPMVTVSGIELSPPVTFRLRTGSGPVFLSG---LECYETSDLTWEDDEEEEE 132

  Fly   123 AEDEEDEH----------PKKRAKIENAADGKNAKNNKKK 152
            .|:||||.          |.|:.|  ..|..|.....|||
Mouse   133 EEEEEDEDEDADISLEEIPVKQVK--RVAPQKQMSIAKKK 170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlp	NP_001263094.1	Nucleoplasmin	6..104	CDD:397268	37/105 (35%)
Npm2	NP_851990.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		1/5 (20%)
		Nucleoplasmin	18..116	CDD:367319	37/108 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..207		19/52 (37%)
		Acidic tract A2. /evidence=ECO:0000250	129..152		6/22 (27%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	165..180		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848744
Domainoid	1	1.000	44	1.000	Domainoid score	I12219
eggNOG	1	0.900	-	-		E1_2C49J
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I5420
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1485080at2759
OrthoFinder	1	1.000	-	-		FOG0000973
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22747
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.900