DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlp and npm1a

DIOPT Version :9

Sequence 1:	NP_001263094.1	Gene:	Nlp / 43560	FlyBaseID:	FBgn0016685	Length:	152	Species:	Drosophila melanogaster
Sequence 2:	NP_955460.2	Gene:	npm1a / 266985	ZFINID:	ZDB-GENE-021028-1	Length:	279	Species:	Danio rerio

Alignment Length:	199	Identity:	52/199 - (26%)
Similarity:	80/199 - (40%)	Gaps:	52/199 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEESF-YGVTLTAESDSVTWDVDEDYARGQKLVIKQILLGAEAKENEFNVVEV---NTPKDSVQ 61
            |..::| ||..|.|..|......|:||  ..:|.::...:....|: |.||||:   ::....|:
Zfish     6 MGPQTFLYGCELKAGKDITFNPEDDDY--DHQLSVRMACVDPSTKD-ELNVVEIEGQDSEGQKVK 67

  Fly    62 IPIAVLKAGETRAVNPDVEFYESKVTFKLIKGSGPVYIHGHNI---------------KDDVEVV 111
            ..:|.||.....:|..........|.|:|..|||||:|.|.::               :::.|.|
Zfish    68 AVLATLKPSTLPSVCLGGFEITPPVVFRLRTGSGPVHISGQHLVIMGGDQSFDEEEEEEEEEETV 132

  Fly   112 ---------------------------DMEEDDEEDDVAEDE-EDEHP--KKRAKIENAADGKNA 146
                                       |.|:||:|||..||| |:|.|  :|:|..:.....:|.
Zfish   133 MTSKKRPALSTPKPSKKMKMDEEDDDDDDEDDDDEDDDEEDESEEESPVKEKKAPAKPKTPTQNG 197

  Fly   147 KNNK 150
            |..|
Zfish   198 KGPK 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlp	NP_001263094.1	Nucleoplasmin	6..104	CDD:397268	31/101 (31%)
npm1a	NP_955460.2	Nucleoplasmin	9..>120	CDD:281111	31/113 (27%)
npm1a	NP_955460.2	NPM1-C	229..277	CDD:292893
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594262
Domainoid	1	1.000	46	1.000	Domainoid score	I12094
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5397
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1485080at2759
OrthoFinder	1	1.000	-	-		FOG0000973
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22747
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.090