DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nph and npm1b

DIOPT Version :9

Sequence 1:	NP_001097975.1	Gene:	Nph / 43559	FlyBaseID:	FBgn0039735	Length:	156	Species:	Drosophila melanogaster
Sequence 2:	XP_005173145.2	Gene:	npm1b / 553507	ZFINID:	ZDB-GENE-080723-7	Length:	316	Species:	Danio rerio

Alignment Length:	166	Identity:	47/166 - (28%)
Similarity:	76/166 - (45%)	Gaps:	42/166 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YGVTLSEKEAIAQFEVPDVPEEYIVHSHKLIIKQISLGPEAKTGEFNVVQAETNINDDGEKKTLK 71
            :|.:|...:...:.::.|...|     |:|.:|.:.||.||: .:|:.|:.| .:..||  ||.|
Zfish    33 FGCSLKADKKEHKVDLDDDEAE-----HQLSLKSVCLGAEAE-DKFHTVEME-GLTYDG--KTTK 88

  Fly    72 IPIAVLKVGETRSLRPNVEFPNGSVT----FKLVQGSGPVHVCGKVEMNFGEFDDGQIYEEY--- 129
            |.:||||    .|:.|::......||    |:|..|.|||::.|:..::..|.||....||.
Zfish    89 ITLAVLK----PSVLPSLSLGGFEVTPPVSFRLQSGGGPVYISGQHFVSVKESDDEDEEEEENNT 149

  Fly   130 ----------------------SDEEEDSELEFDEE 143
                                  |||:|||:.:.|::
Zfish   150 SPVKRPSNMTLAKVPQKKLKMDSDEDEDSDDDDDDD 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nph	NP_001097975.1	Nucleoplasmin	6..112	CDD:397268	34/108 (31%)
npm1b	XP_005173145.2	Nucleoplasmin	32..131	CDD:308605	35/110 (32%)
npm1b	XP_005173145.2	NPM1-C	265..313	CDD:318505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594269
Domainoid	1	1.000	46	1.000	Domainoid score	I12094
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5397
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1485080at2759
OrthoFinder	1	1.000	-	-		FOG0000973
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_111063
Panther	1	1.100	-	-	O	PTHR22747
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.900