DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nph and npm1a

DIOPT Version :10

Sequence 1:NP_651760.1 Gene:Nph / 43559 FlyBaseID:FBgn0039735 Length:156 Species:Drosophila melanogaster
Sequence 2:NP_955460.2 Gene:npm1a / 266985 ZFINID:ZDB-GENE-021028-1 Length:279 Species:Danio rerio


Alignment Length:210 Identity:56/210 - (26%)
Similarity:80/210 - (38%) Gaps:70/210 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MESESF-YGVTLSEKEAIAQFEVPDVPEEYIVHSHKLIIKQISLGPEAKTGEFNVVQAETNINDD 64
            |..::| ||..|...:.|. |...|  ::|   .|:|.::...:.|..| .|.|||:.|   ..|
Zfish     6 MGPQTFLYGCELKAGKDIT-FNPED--DDY---DHQLSVRMACVDPSTK-DELNVVEIE---GQD 60

  Fly    65 GEKKTLKIPIAVLKVGETRSLRPNVEFPNGSVT----FKLVQGSGPVHVCGK------------- 112
            .|.:.:|..:|.||    .|..|:|......:|    |:|..||||||:.|:             
Zfish    61 SEGQKVKAVLATLK----PSTLPSVCLGGFEITPPVVFRLRTGSGPVHISGQHLVIMGGDQSFDE 121

  Fly   113 --------------------------VEMNFGEFDDGQIYEEYSDEEEDSELEFDEE-------- 143
                                      .:|...|.||....|:..||::|.|.|.:||        
Zfish   122 EEEEEEEEETVMTSKKRPALSTPKPSKKMKMDEEDDDDDDEDDDDEDDDEEDESEEESPVKEKKA 186

  Fly   144 -AAPQT---NGKSNK 154
             |.|:|   |||..|
Zfish   187 PAKPKTPTQNGKGPK 201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NphNP_651760.1 Nucleoplasmin 6..112 CDD:460792 35/110 (32%)
npm1aNP_955460.2 Nucleoplasmin 12..111 CDD:460792 35/112 (31%)
NPM1-C 229..277 CDD:465081
Blue background indicates that the domain is not in the aligned region.

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