DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nph and Npm1

DIOPT Version :10

Sequence 1:NP_651760.1 Gene:Nph / 43559 FlyBaseID:FBgn0039735 Length:156 Species:Drosophila melanogaster
Sequence 2:NP_032748.1 Gene:Npm1 / 18148 MGIID:106184 Length:292 Species:Mus musculus


Alignment Length:170 Identity:45/170 - (26%)
Similarity:74/170 - (43%) Gaps:59/170 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 HSHKLIIKQISLGPEAKTGEFNVVQAETNINDDGEKKTLKIPIAVLKVGETRSLRPNVEFPNGSV 96
            :.|:|.::.:|||..|| .|.::|:||. :|.:|  ..:|:.:|.||:    |::|.|......:
Mouse    38 NEHQLSLRTVSLGAGAK-DELHIVEAEA-MNYEG--SPIKVTLATLKM----SVQPTVSLGGFEI 94

  Fly    97 T----FKLVQGSGPVHVCG-----------------------------------------KVEMN 116
            |    .:|..||||||:.|                                         ||:::
Mouse    95 TPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLD 159

  Fly   117 FGEFDDGQIYEEYSDEEEDSELEFDEEAAPQTNGKSNKKK 156
            ..:.||.   |:..|:|:|.:.:||||   :|..|...||
Mouse   160 EDDEDDD---EDDEDDEDDDDDDFDEE---ETEEKVPVKK 193

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NphNP_651760.1 Nucleoplasmin 6..112 CDD:460792 29/124 (23%)
Npm1NP_032748.1 Required for interaction with SENP3. /evidence=ECO:0000250 1..185 41/160 (26%)
Necessary for interaction with APEX1. /evidence=ECO:0000250 1..117 29/86 (34%)
Nucleoplasmin 18..117 CDD:460792 29/86 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..248 16/62 (26%)
Nuclear localization signal. /evidence=ECO:0000255 152..157 1/4 (25%)
Interaction with NOP2. /evidence=ECO:0000250|UniProtKB:P06748 186..214 3/8 (38%)
Nuclear localization signal. /evidence=ECO:0000255 190..196 2/4 (50%)
Required for nucleolar localization. /evidence=ECO:0000250 241..292
NPM1-C 243..291 CDD:465081
Blue background indicates that the domain is not in the aligned region.

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