Protein Alignment Tace and ADAM9

DIOPT Version :9

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_016869431.1
• Gene: ADAM9 / 8754
• HGNCID: 216
• Length: 821
• Species: Homo sapiens
• Alignment Length: 853
• Identity: 189/853 - (22%)
• Similarity: 292/853 - (34%)
• Gaps: 251/853 - (29%)

  Fly    15 SVFFACLFVENCAALQKT--LRHYEIFHKDDVVHRVVKRGAKHSTNPFNTIKEVEFT--TLGKNF 75
            ||.|..:...||::.|:|  |..|||     :....:.|..:.:..|::  |:|.:.  ..||..
Human    22 SVRFGEVKHTNCSSFQQTSHLSSYEI-----ITPWRLTRERREAPRPYS--KQVSYVIQAEGKEH 79

  Fly    76 RLILHPHRDVLHSKFRAYAVDADGNETVVH--MDHDSFYSGRVFGELESSVRAHIEDGTMTMSIH 138
            .:.|..::|:|...|..|..:.:|.....|  :.:...|.|.|.|...||:......|...: :|
Human    80 IIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGL-LH 143

  Fly   139 LPEETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYIKEGLELE---DKEHGDT 200
            |...:|.|||    |..:.....:.|:..|  |:|.     |..||...:.:|.|   |:|....
Human   144 LENASYGIEP----LQNSSHFEHIIYRMDD--VYKE-----PLKCGVSNKDIEKETAKDEEEEPP 197

  Fly   201 LDNELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNT--KTTINYLISLIDRVHKIYN 263
            ...:|..|.:....|..|.      .|.:|.|...:..||...|  :..:..|.:.:|.::.:.|
Human   198 SMTQLLRRRRAVLPQTRYV------ELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLN 256

  Fly   264 D-------TVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRNLLEVFSRE 321
            .       .:|.:.:......|.|.|:...|                    :|  |....:..|.
Human   257 IRIVLVGLEIWTNGNLINIVGGAGDVLGNFV--------------------QW--REKFLITRRR 299

  Fly   322 YSHKDFCLAHLFTDLKFEGGILGLAYVGSP-RRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYG 385
            :......|...|      ||..|:|:||:. .|:..|||                      |.:|
Human   300 HDSAQLVLKKGF------GGTAGMAFVGTVCSRSHAGGI----------------------NVFG 336

  Fly   386 QRVITREADLVTAHEFGHNWGSEHDPDIPECSPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRS 450
            |..:...|.:| |||.|||.|..|| |..:||..|.   |.:|.: ..||    ::.||.||...
Human   337 QITVETFASIV-AHELGHNLGMNHD-DGRDCSCGAK---SCIMNS-GASG----SRNFSSCSAED 391

  Fly   451 IRKVLQAKSGRC---FSEPEESF----CGNLRVEGDEQCDAGLLGTEDNDSCCD-KNCKLRRNQG 507
            ..|:...|.|.|   ..:|:|::    |||..|:..|:||.|.....:.|.||: ..|||:  ..
Human   392 FEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLK--SF 454

  Fly   508 AMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQ-ERGQCRN 571
            |.|:  ...||::|:|:..|..|| .:.:.|:....|.|:...|.....:.:|..|| .:..|.|
Human   455 AECA--YGDCCKDCRFLPGGTLCR-GKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYN 516

  Fly   572 GKCVPYCETQGLQSCMCDII----ADACKRCCRMSINE--------------------------- 605
            |.|..|       ...|.:|    |.|..:.|.:.:|.
Human   517 GMCQYY-------DAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGK 574

  Fly   606 --------------------------TCFPVE--------PPDVLPDGTPCITG-FCNK------ 629
                                      .|:.|:        .|.::.:||.|..| .|..
Human   575 LQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDA 639

  Fly   630 ----------------GVCEKTIQDVVERFW-----------------DIIEEINVAKTLRFLKD 661
                            |||........|..|                 ....|:|.|     |:|
Human   640 SVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTA-----LRD 699

  Fly   662 NIVMAVVLVTAVFWIPISCVI-----------SYFDRKKLRHEMKLIEWSQKLDLIHPSDERRRV 715
            .:::...|:..:    |.|.|           ||| |||.....:....:|......|....|.|
Human   700 GLLVFFFLIVPL----IVCAIFIFIKRDQLWRSYF-RKKRSQTYESDGKNQANPSRQPGSVPRHV 759

  Fly   716 IHIRVPRQ 723
            ..:..||:
Human   760 SPVTPPRE 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	27/115 (23%)
		ZnMc_TACE_like	223..470	CDD:239798	61/259 (24%)
		Reprolysin_2	244..456	CDD:290307	51/221 (23%)
		Disintegrin	477..552	CDD:278623	22/75 (29%)
		ADAM17_MPD	576..633	CDD:271205	17/144 (12%)
ADAM9	XP_016869431.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920