DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tace and ADAM12

DIOPT Version :9

Sequence 1:NP_733334.1 Gene:Tace / 43558 FlyBaseID:FBgn0039734 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_003465.3 Gene:ADAM12 / 8038 HGNCID:190 Length:909 Species:Homo sapiens


Alignment Length:807 Identity:189/807 - (23%)
Similarity:281/807 - (34%) Gaps:287/807 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 LILHPHRD--VLHSKFRAYAVDADG-------NETVVHMDHDSFYSGRVFGELESSVRAHIEDGT 132
            ||::..|:  ::.|.|.......||       |.||: :.| .:|.|.|.|..:|:|......|.
Human    79 LIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVI-LGH-CYYHGHVRGYSDSAVSLSTCSGL 141

  Fly   133 MTMSIHLPEETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYIKEGLELEDKEH 197
            ..: |....|:|.:||        .|.....||....|..|:..|    :||           .|
Human   142 RGL-IVFENESYVLEP--------MKSATNRYKLFPAKKLKSVRG----SCG-----------SH 182

  Fly   198 GDTLD--------------NELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTI 248
            .:|.:              ...|.||..::.:|        ..|::|||.|.||..|....|.. 
Human   183 HNTPNLAAKNVFPPPSQTWARRHKRETLKATKY--------VELVIVADNREFQRQGKDLEKVK- 238

  Fly   249 NYLISLIDRVHKIYND----------TVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYN 303
            ..||.:.:.|.|.|..          .||.|             :.|..|..:|         :.
Human   239 QRLIEIANHVDKFYRPLNIRIVLVGVEVWND-------------MDKCSVSQDP---------FT 281

  Fly   304 MIREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNG 368
            .:.|..|.|. :::..|: ||.:   |.|.:.:.|:|..:|:|.:.|        :||.:     
Human   282 SLHEFLDWRK-MKLLPRK-SHDN---AQLVSGVYFQGTTIGMAPIMS--------MCTAD----- 328

  Fly   369 YTLYLNSG---LSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPECS--PSASQGGSFLM 428
                 .||   :..|.|..|       |.:..|||.|||:|..||.....||  .:..:||..: 
Human   329 -----QSGGIVMDHSDNPLG-------AAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIM- 380

  Fly   429 YTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRC-FSEPE--ESF----CGNLRVEGDEQCDAGL 486
              .:.:||.. ...||.||.:.:...|:...|.| |:.||  |||    |||..||..|:||.| 
Human   381 --NASTGYPF-PMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCG- 441

  Fly   487 LGTEDNDSCCD-KNCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAE 550
            ...|..:.||: ..|.|:.:  |:|:  :..||::||...:|..||::. .:|:....||||...
Human   442 EPEECMNRCCNATTCTLKPD--AVCA--HGLCCEDCQLKPAGTACRDSS-NSCDLPEFCTGASPH 501

  Fly   551 CPKSPAMADGTTCQE-RGQCRNGKCVPYCETQGLQSCM--------------------------- 587
            ||.:..:.||.:||: .|.|.||    .|:|.. |.|:                           
Human   502 CPANVYLHDGHSCQDVDGYCYNG----ICQTHE-QQCVTLWGPGAKPAPGICFERVNSAGDPYGN 561

  Fly   588 CDIIADACKRCCRM------------------------SINETCFPVEP-------------PDV 615
            |..::.:....|.|                        || ||..|::.             .|.
Human   562 CGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSI-ETNIPLQQGGRILCRGTHVYLGDD 625

  Fly   616 LPD------GTPCITG-FC---------------------NKGVCEKTIQDVVERFW-------- 644
            :||      ||.|..| .|                     .:|||........|..|        
Human   626 MPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKF 690

  Fly   645 ---------DIIEEINVAKTLRFLKDNIVMAVVLVTAVFWIPISCVISYFDRKKLRHEMKLIEWS 700
                     .|.:..|...|:..|    |..:.|:.|.|       :.|..||.|   ::|:..:
Human   691 GFGGSTDSGPIRQADNQGLTIGIL----VTILCLLAAGF-------VVYLKRKTL---IRLLFTN 741

  Fly   701 -----QKLDLIHPSDERRRVIHIRVPR 722
                 :||..:.||         |.||
Human   742 KKTTIEKLRCVRPS---------RPPR 759

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TaceNP_733334.1 Pep_M12B_propep 50..162 CDD:279848 24/93 (26%)
ZnMc_TACE_like 223..470 CDD:239798 67/264 (25%)
Reprolysin_2 244..456 CDD:290307 52/226 (23%)
Disintegrin 477..552 CDD:278623 24/75 (32%)
ADAM17_MPD 576..633 CDD:271205 22/148 (15%)
ADAM12NP_003465.3 Pep_M12B_propep 60..161 CDD:279848 24/92 (26%)
Cysteine switch. /evidence=ECO:0000250 177..184 4/21 (19%)
Reprolysin 214..416 CDD:279729 65/266 (24%)
ZnMc_adamalysin_II_like 214..414 CDD:239797 64/264 (24%)
DISIN 439..507 CDD:214490 23/73 (32%)
ACR 510..652 CDD:214743 28/147 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..862
SH3-binding, class II. /evidence=ECO:0000250 828..834
SH3-binding, class I. /evidence=ECO:0000250 834..841
SH3-binding, class I. /evidence=ECO:0000250 885..891
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4147
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.950

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