DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tace and adam15

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_001335318.4	Gene:	adam15 / 795199	ZFINID:	ZDB-GENE-070809-4	Length:	992	Species:	Danio rerio

Alignment Length:	596	Identity:	152/596 - (25%)
Similarity:	217/596 - (36%)	Gaps:	179/596 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 TVVHMDHDSFYSGRVFGELESSVRAHIEDG-------TMTMSIHLPEETYHIEPSWRHLPEAKKD 159
            ||.|    .:|.|.|.|..||.|......|       ..|:|..|             |||.::
Zfish   142 TVTH----CYYHGSVQGFPESRVALSSCSGLRGVIVINATLSFEL-------------LPEGEE- 188

  Fly   160 TMVAYKASDVKVHKNEAGATPKTCGYIKEG-LELEDKEHGDTLDNE----LHT------------ 207
                           |.|...:..|.::|| :......|..|.::.    .||
Zfish   189 ---------------ERGKDDEGSGEMEEGEMHAIYSTHSPTSESRDCGVSHTSIPPIQIIPHTH 238

  Fly   208 REKRQ-SDQYEYTPTKTRCPLLLVAD---YRFFQEMGGGNTKTTINYLISLIDRVHKIYND---- 264
            |.||. ..:.:|      ..|:||||   |..:|:    |.||.|..::.:.::|...|..
Zfish   239 RSKRDILSEIKY------IELVLVADHKEYLNYQK----NNKTIIYRMLDVANQVDWFYRPLNVR 293

  Fly   265 ------TVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRNLLEVFSREYS 323
                  .:|   |||:          ||.|...||..      .|...: |..|.||.    ...
Zfish   294 VALLGLEIW---SDQD----------KIKVDKSPTET------LNRFLD-WRTRELLP----RLR 334

  Fly   324 HKDFCLAHLFTDLKFEGGILGLAYVGSP-RRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQR 387
            |.:   |.|.....|:|..:|:|...|. .::..||:       |...|....|::|:
Zfish   335 HDN---AQLIMGESFDGTTVGMASQSSMCSKDRSGGV-------NVDHLVSVLGVAST------- 382

  Fly   388 VITREADLVTAHEFGHNWGSEHDPDIP--ECSPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRS 450
                     .|||.|||.|..||....  .|......||..:..:   :|: :..:.||.||.|.
Zfish   383 ---------VAHELGHNLGMSHDTADRRCHCQNEPRLGGCIMEPS---TGF-MPGQLFSSCSERD 434

  Fly   451 IRKVLQAKSGRC-FSEPE-ESF-----CGNLRVEGDEQCDAGLLGTEDNDSCCD-KNCKLRRNQG 507
            :...|....|.| |:.|: ||.     ||||.||..|:||.||| .|.||.||: ..|||  ..|
Zfish   435 LSLSLLHGGGMCLFNVPQPESLLGGPRCGNLYVEKGEECDCGLL-DECNDPCCNASTCKL--VPG 496

  Fly   508 AMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERGQCRNG 572
            |.|| .:..||:||:...:|..||| ....|:....|||:...||.:..:.:|.      .|:.|
Zfish   497 AQCS-SDGICCENCKLRVAGSVCRE-PLGECDLPEHCTGSSPYCPPNVFLQNGE------PCKGG 553

  Fly   573 KCVPYCETQGLQSCMCDIIADACKR-----------CCRMSINETCFPVEPPDVLPDGT--PCIT 624
            .  .||     .|.:|..:.|.|:.           .|..|:|:..........:|:|:  ||:.
Zfish   554 S--SYC-----YSGVCASLDDQCQMLWGQNSTRAPPICFSSVNKQGNKYGNCGQMPNGSYIPCLK 611

  Fly   625 G--FCNKGVCE 633
            .  .|.:..|:
Zfish   612 WDVHCGRIQCQ 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	17/66 (26%)
		ZnMc_TACE_like	223..470	CDD:239798	65/264 (25%)
		Reprolysin_2	244..456	CDD:290307	51/224 (23%)
		Disintegrin	477..552	CDD:278623	31/75 (41%)
		ADAM17_MPD	576..633	CDD:271205	14/71 (20%)
adam15	XP_001335318.4	Pep_M12B_propep	83..>175	CDD:279848	11/36 (31%)
		Reprolysin	249..451	CDD:279729	64/265 (24%)
		ZnMc_adamalysin_II_like	249..449	CDD:239797	63/263 (24%)
		Disintegrin	468..542	CDD:278623	33/78 (42%)
		ACR	545..687	CDD:214743	18/91 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950