DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tace and ADAM17

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_003174.3	Gene:	ADAM17 / 6868	HGNCID:	195	Length:	824	Species:	Homo sapiens

Alignment Length:	711	Identity:	297/711 - (41%)
Similarity:	422/711 - (59%)	Gaps:	62/711 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LQKTLRHYEIFHKDDV-VHRVVKRGAKHSTNPFNTIKEVEFTTLGKNFRLILHPHRDVLHSKFRA 92
            |...|..|:|....:: .|.|.||..:.||: ..|:  :.|:.|.::|:|.|....:.....|:.
Human    35 LDSLLSDYDILSLSNIQQHSVRKRDLQTSTH-VETL--LTFSALKRHFKLYLTSSTERFSQNFKV 96

  Fly    93 YAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAK 157
            ..||.. ||:...:....|::|.|.||.:|.|.|||.|..:.:.|:.....|:|||.||.:.:.|
Human    97 VVVDGK-NESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTK 160

  Fly   158 KDTMVAYKASDVK-VHKNEAGATPKTCGYIKEGLE------LEDKEHGDTLDNELHTREKRQSDQ 215
            ...|:.||:.|:| |.:.:   :||.|||:|...|      |.|:|..:    ||..|.||::|.
Human   161 DKRMLVYKSEDIKNVSRLQ---SPKVCGYLKVDNEELLPKGLVDREPPE----ELVHRVKRRADP 218

  Fly   216 YEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMG 280
               .|.|..|.||:|||:||::.||.|...||.||||.|||||..||.:|.|    |..||||.|
Human   219 ---DPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSW----DNAGFKGYG 276

  Fly   281 FVIKKIVVHSEPTRLRGGEAHYNMI-------REKWDVRNLLEVFSREYSHK--DFCLAHLFTDL 336
            ..|::|.:...|..::.||.||||.       ::.|||:.|||.||.:.:.:  ..|||||||..
Human   277 IQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQ 341

  Fly   337 KFEGGILGLAYVGSPRRNSVGGICTPEYF-----KNGYTLYLNSGLSSSRNHYGQRVITREADLV 396
            .|:.|.||||||||||.||.||:|...|:     ||   :||||||:|::| ||:.::|:|||||
Human   342 DFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKN---IYLNSGLTSTKN-YGKTILTKEADLV 402

  Fly   397 TAHEFGHNWGSEHDPD-IPECSPSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSG 460
            |.||.|||:|:||||| :.||:|:..|||.::||..:|||...|||.||.||.:||.|.:::|:.
Human   403 TTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQ 467

  Fly   461 RCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCCDKNCKLRRNQGAMCSDKNSPCCQNCQFMA 525
            .||.|.....|||.||:..|:||.|::.. :||:||:.:|.|:  :|..|||:|||||:||||..
Human   468 ECFQERSNKVCGNSRVDEGEECDPGIMYL-NNDTCCNSDCTLK--EGVQCSDRNSPCCKNCQFET 529

  Fly   526 SGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERGQCRNGKCVPYCE-TQGLQSCMCD 589
            :..||:||..|||:..:.|||..:|||......|.|.|.:.|:|::|||:|:|| .|.|:||.|:
Human   530 AQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACN 594

  Fly   590 IIADACKRCCRMSINETCFPVEPPD----VLPDGTPCITGFCN-KGVCEKTIQDVVERFWDIIEE 649
            ...::||.||| .::..|.|....:    .|..|.||..|||: .|.|||.:|||:|||||.|::
Human   595 ETDNSCKVCCR-DLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQ 658

  Fly   650 INVAKTLRFLKDNIVMAVVLVTAVFWIPISCVISYFDRKKLRHEMKLIEWSQKLDLIHPSD 710
            :::....:||.||||.:|::.:.:||||.|.::...|:       ||.:..:.|.|.|||:
Human   659 LSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDK-------KLDKQYESLSLFHPSN 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	34/111 (31%)
		ZnMc_TACE_like	223..470	CDD:239798	129/261 (49%)
		Reprolysin_2	244..456	CDD:290307	114/226 (50%)
		Disintegrin	477..552	CDD:278623	34/74 (46%)
		ADAM17_MPD	576..633	CDD:271205	23/62 (37%)
ADAM17	NP_003174.3	Pep_M12B_propep	56..152	CDD:307618	30/99 (30%)
		Cysteine switch. /evidence=ECO:0000250	182..189		4/6 (67%)
		ZnMc_TACE_like	223..477	CDD:239798	129/261 (49%)
		DISIN	484..560	CDD:214490	36/78 (46%)
		ADAM17_MPD	581..641	CDD:318829	22/60 (37%)
		Crambin-like	603..671		27/68 (40%)
		SH3-binding. /evidence=ECO:0000255	731..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..824
		SH3-binding. /evidence=ECO:0000255	741..748
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147238
Domainoid	1	1.000	225	1.000	Domainoid score	I2558
eggNOG	1	0.900	-	-		E1_KOG3658
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2395
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1264
Isobase	1	0.950	-	0	Normalized mean entropy	S5135
OMA	1	1.010	-	-		QHG52269
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0006183
OrthoInspector	1	1.000	-	-		oto89661
orthoMCL	1	0.900	-	-		OOG6_106716
Panther	1	1.100	-	-	LDO	PTHR45702
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X4463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750