DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tace and adam10a

DIOPT Version :9

Sequence 1:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_005168953.1	Gene:	adam10a / 566044	ZFINID:	ZDB-GENE-040917-2	Length:	763	Species:	Danio rerio

Alignment Length:	692	Identity:	203/692 - (29%)
Similarity:	306/692 - (44%)	Gaps:	125/692 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VFFACLFVENCAA---------LQKTLRHYE-IFHKDDVVHRVVKRGAKHSTNPFNTIKEVEFTT 70
            |.|..|.:..|.:         |.|.:|||| :.:..||:|...:| ||.:.:..:....:||..
Zfish     7 VLFKLLILLYCLSDSNGQYGKPLNKYIRHYEGLSYDTDVLHSKHQR-AKRALSHQDQFIHLEFHA 70

  Fly    71 LGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTM 135
            .|::|.|.:.....:.....:   |:..|.|  |..|....|:|.::||.:|.....:.||....
Zfish    71 HGRHFNLRMKRDTSLFTHNLK---VEVSGVE--VPYDTSHIYTGEIYGEKDSLTHGSVVDGKFEG 130

  Fly   136 SIHLPEETYHIEPSWRHLPEAKKDTMVAYKA-----SDVKV-HK--NEAGATPKTC-----GYIK 187
            .|.....||::|||.|:|    ||..|.|.:     .|:.. ||  :|.|....:.     .|..
Zfish   131 FIKSHHGTYYVEPSERYL----KDQNVPYHSVIYHEDDIDYPHKYGSEGGCADHSVFERMKKYQA 191

  Fly   188 EGLELEDKEHGDTLDNE-------LHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTK 245
            ..:|...::....:|.|       |.||...|::       |..|.|.:..|:.||:..  |:.:
Zfish   192 SAMEEPTQQTNHIIDEEVADGPVILRTRRAAQAE-------KNTCQLFIQTDHLFFKYY--GSRE 247

  Fly   246 TTINYLISLIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVH--------SEPTRLRGGEAHY 302
            ..|..:.|.:..::.||..|      |.:|.:.:.|::|:|.::        |.|.|..
Zfish   248 AVIAQISSHVKAINSIYQGT------DFQGIRNISFMVKRIKINTTIDEKDSSNPFRFG------ 300

  Fly   303 NMIREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTP-EYFK 366
            |:..||:     ||:.| |.:|.::|||::|||..|:.|:||||:||:|..:| ||||.. :.:.
Zfish   301 NIGVEKF-----LELNS-EQNHDEYCLAYVFTDRDFDDGVLGLAWVGAPSGSS-GGICEKNKQYS 358

  Fly   367 NGYTLYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPECSPSAS------QGGS 425
            :|....||:|:.:.:| |...|..:.:.:..|||.|||:||.||.. .:|:|..|      :.|:
Zfish   359 DGKKKSLNTGIITVQN-YASHVPPKVSHITFAHEVGHNFGSPHDSG-SDCTPGESKTTDQKEKGN 421

  Fly   426 FLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLLGTE 490
            ::||..:.||...||.|||.||:|:|.:||..|...||.|..:..|||..||.:|:||.| ...:
Zfish   422 YIMYARATSGDKFNNNKFSICSVRNISQVLDKKRSACFVESGQPICGNGLVETNEECDCG-YNDQ 485

  Fly   491 DNDSCC-------DKNCKLR----RNQGAMCSDKNSPCC-QNCQFMASGMKCREAQYATCEQEAR 543
            ..|.||       .|.|||:    ......||....||| ..|.: .:|.:||..  :.|..:..
Zfish   486 CKDQCCYSADEPEGKKCKLKPETESKSKVFCSPSQGPCCTPQCTY-RTGNECRPE--SDCAFKGL 547

  Fly   544 CTGAHAECPKSPAMADGTTCQERGQ-CRNGKCV-PYCETQGLQSCMC-------DIIADACKRCC 599
            |.|..|:||.|....:.|.|....| |.||.|. ..||...|..|.|       |:  :.|..||
Zfish   548 CNGLSAQCPASTPKENYTACHANTQVCINGGCSGSICEKHKLDVCTCATEDGKDDM--ELCHVCC 610

  Fly   600 -RMSINETC----------FPVEPPDVLPDGTPC--ITGFCN 628
             ......||          |.......|..|:||  ..|:|:
Zfish   611 MEKGKPSTCSSTSSERWASFFDNKVITLQPGSPCNDFKGYCD 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	30/111 (27%)
		ZnMc_TACE_like	223..470	CDD:239798	87/261 (33%)
		Reprolysin_2	244..456	CDD:290307	76/226 (34%)
		Disintegrin	477..552	CDD:278623	25/86 (29%)
		ADAM17_MPD	576..633	CDD:271205	18/73 (25%)
adam10a	XP_005168953.1	Pep_M12B_propep	54..151	CDD:279848	27/105 (26%)
		ZnMc_TACE_like	227..466	CDD:239798	87/261 (33%)
		Reprolysin_2	247..452	CDD:290307	76/225 (34%)
		DISIN	473..559	CDD:214490	27/89 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3658
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820