Protein Alignment Tace and adam12b

DIOPT Version :9

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_021323120.1
• Gene: adam12b / 563275
• ZFINID: ZDB-GENE-070809-1
• Length: 941
• Species: Danio rerio
• Alignment Length: 547
• Identity: 141/547 - (25%)
• Similarity: 218/547 - (39%)
• Gaps: 128/547 - (23%)

  Fly    76 RLILHPHRDVLHSKFRAYAVDA----DGNETVVHMDHDS----FYSGRVFGELESSVRAHIEDGT 132
            :|||...::  |..|.::..:.    ||.  .|...|:|    :|.|.|.|.:.|.|......|.
Zfish    89 QLILSVEKN--HGLFASHYTETHYREDGQ--TVTSTHNSTMNCYYHGEVQGYVHSEVTLSTCSGI 149

  Fly   133 MTMSIHLPEETYHIEPSWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYIKEGLELEDKEH 197
            ... :.|..:|..:||::    |...||.|.|....:.....       |||:   |..:....:
Zfish   150 RGF-VLLENKTLMVEPAF----EPANDTHVIYDGHHLHFPSG-------TCGH---GHNISTVSN 199

  Fly   198 GDT--LDNELHTREKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGG--NTKTTINYLISLIDRV 258
            .:|  |.....||.||     :...|.....|::|||.|.||:.|..  ..|..:..:.:.:|:.
Zfish   200 TNTRGLLQSFRTRHKR-----DVQKTTKYVELIIVADNREFQKQGKDVEKVKQRLAEIANYVDKF 259

  Fly   259 HKIYND-------TVWQDRSDQEGFKGMGFVIKKIVVHSEPTRLRGGEAHYNMIREKWDVRNLLE 316
            :::.|.       .||.|             :.|..|..:|         :..:.|..|.|.|..
Zfish   260 YRVLNIRVALVGLEVWSD-------------VDKCSVTQDP---------FTTLHEFLDWRKLKL 302

  Fly   317 VFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYTLYLNSG---LS 378
            :..|.:.:     |.|.:.:.|:|..:|:|.:.|        :||.|          .||   :.
Zfish   303 LPQRPHDN-----AQLISGVYFQGTTIGMAPIMS--------MCTAE----------QSGGIVMD 344

  Fly   379 SSRNHYGQRVITREADLVTAHEFGHNWGSEHDPDIPE----CSPSASQGGSFLMYTYSVSGYDVN 439
            .|.|..|       |.:..|||.|||:|..|  |.||    |..:..:||..:..:   :||...
Zfish   345 HSDNALG-------AAVTLAHELGHNFGMNH--DTPERGCGCRMTVDRGGCIMTPS---TGYPFP 397

  Fly   440 NKKFSPCSLRSIRKVLQAKSGRC-FSEPEESF------CGNLRVEGDEQCDAGLLGTEDNDSCCD 497
            . .||.||.:.:...|:...|.| ::.||...      |||..:|..|:||.| ...|..:.||:
Zfish   398 T-VFSTCSKKDLVASLEKGVGMCLYNMPEVKMLYGGQKCGNGYIEEGEECDCG-EPEECLNPCCN 460

  Fly   498 -KNCKLRRNQGAMCSDKNSPCCQNCQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGT 561
             ..|.|:.:  |:|:  :..||:|||...:|..|||:. .:|:....|||.:..||.:..:.||.
Zfish   461 ATTCTLKGD--AVCA--HGQCCENCQLKPAGTPCRESS-NSCDLPEFCTGTNPHCPANVYLHDGH 520

  Fly   562 TCQER-GQCRNGKCVPYCETQGLQSCM 587
            .|... |.|.||    .|:|.. |.|:
Zfish   521 ACHNMDGYCYNG----ICQTHE-QQCI 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	24/93 (26%)
		ZnMc_TACE_like	223..470	CDD:239798	63/263 (24%)
		Reprolysin_2	244..456	CDD:290307	50/225 (22%)
		Disintegrin	477..552	CDD:278623	25/75 (33%)
		ADAM17_MPD	576..633	CDD:271205	4/12 (33%)
adam12b	XP_021323120.1	Pep_M12B_propep	72..176	CDD:307618	25/95 (26%)
		ZnMc_adamalysin_II_like	222..422	CDD:239797	61/257 (24%)
		DISIN	447..515	CDD:214490	24/73 (33%)
		ACR	518..660	CDD:214743	11/30 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920