Protein Alignment Tace and si:ch1073-396h14.1

DIOPT Version :10

• Sequence 1: NP_733334.1
• Gene: Tace / 43558
• FlyBaseID: FBgn0039734
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_689465.6
• Gene: si:ch1073-396h14.1 / 560975
• ZFINID: ZDB-GENE-070705-6
• Length: 683
• Species: Danio rerio
• Alignment Length: 654
• Identity: 181/654 - (27%)
• Similarity: 297/654 - (45%)
• Gaps: 102/654 - (15%)

  Fly    22 FVENCAALQKTLRHYE-IFHKDDVV----HRVVKRGAKHSTNPFNTIKEVEFTTLGKNFRLILHP 81
            |.|...|:.|.::||| :.:..::|    ||:     :...||......::|:...:.|.|.|.|
Zfish    23 FTEASQAISKYIKHYEGLSYDRELVKQHQHRI-----RRDANPNKQDLHLDFSAFQREFHLRLTP 82

  Fly    82 HRDVLHSKFRAYAVDADGNETVVHMDHDSFYSGRVFGELESSVRAHIEDGTMTMSIHLPEETYHI 146
              ||.:.....:.|.::....:|.:.|  .|||.:..:.:||.:..:.:|....||.....|:::
Zfish    83 --DVNNGFTEDFKVQSENESQMVDLSH--IYSGVLEDDSKSSCQGSVLEGQFEGSITTSNGTFYV 143

  Fly   147 EPSWRHLPEAKKDTMVAYKASDVKVHKNEAGATPKTCGYI----KEGLELEDKEHGDTLDNELHT 207
            ||..|:.........:.|       |:::...||...|:.    .|.|:...:.|.:.:.   .:
Zfish   144 EPIERYKTTHSDHHSIIY-------HEDDVDDTPLRSGHAGFCGAERLQNLLQNHQEQIP---VS 198

  Fly   208 REKRQSDQYEYTPTKTRCPLLLVADYRFFQEMGGGNTKTTINYLISLIDRVHKIYNDTVWQDRSD 272
            |.||:.||     :||.|.|.|..|:|:::..|      :|..:::.:....|..||.  .|:::
Zfish   199 RSKRKVDQ-----SKTSCLLHLHTDHRYYKRFG------SIEAIVAQVASYMKAVNDV--YDKAN 250

  Fly   273 QEGFKGMGFVIKKIVVHSE-----PTRLR--GGEAHYNMIREKWDVRNLLEVFSREYSHKDFCLA 330
            .:|.:.:.|.:|.:.|.:|     |..:.  |.|             .||.:|| |.:..||||:
Zfish   251 FDGIELINFKVKFLTVITEEDPSSPISVTHVGPE-------------KLLSLFS-ETNWNDFCLS 301

  Fly   331 HLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNGYTLYLNSGLSSSRNHYGQRVITREADL 395
            :|.||..| .|:||||:.|  :.::.||||:....|:|.....|:||.:.:. ||..:.|:...|
Zfish   302 YLLTDRDF-SGVLGLAWEG--KADNWGGICSKMILKSGRNCSHNTGLVTLQT-YGHYLSTKHVHL 362

  Fly   396 VTAHEFGHNWGSEHDPDIPECS--PSASQGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAK 458
            ..|||.||:.|:.||.: ..|.  ...|..|.|||:..:.|..:.|:.||||||||.:..:|..|
Zfish   363 TFAHELGHSLGAPHDEN-SNCGDLEVTSGKGRFLMFPKAASRIEENSDKFSPCSLRHMSHLLNVK 426

  Fly   459 SGRCFSEPEESFCGNLRVEGDEQCDAGLLGTEDNDSCCDKN-------CKLRRNQGAMCSDKNSP 516
            ...||.:.::..|||..||..|:||   :|.:|:|.||..:       |:|:  .|..||.....
Zfish   427 KDTCFVDSDQPICGNRIVEEGEECD---VGHDDSDPCCHSSKEPSGIECRLK--LGKQCSPSQGL 486

  Fly   517 CCQN-CQFMASGMKCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQERGQ-CRNGKC-VPYC 578
            ||.: |.|..:|:.|.  ..:.|..::.|.|:.|.||:.|:..|.|.|....: |.:|:| :..|
Zfish   487 CCNSQCVFKKAGLMCE--GNSECRNKSVCAGSSAVCPEPPSKPDMTICSNGTRVCSSGECGLSLC 549

  Fly   579 ETQGLQSCMC--DIIADACKRCCRMSIN-ETCFPVEPPDV----------LPDGTPCITGFCNKG 630
            ....:..|.|  ....:.|..||:.... .||.......:          |..|.|| :|  |:|
Zfish   550 ALHNMVQCDCPGQSKTEKCHMCCQQRDKPNTCASTTSAVLLQYFSGKRVALAPGAPC-SG--NQG 611

  Fly   631 VCEK 634
            .|::
Zfish   612 YCDQ 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tace	NP_733334.1	Pep_M12B_propep	44..164	CDD:460254	27/123 (22%)
		ZnMc_TACE_like	223..470	CDD:239798	80/255 (31%)
		Disintegrin	477..552	CDD:459709	24/82 (29%)
		ADAM17_MPD	576..633	CDD:271205	15/69 (22%)
si:ch1073-396h14.1	XP_689465.6	Pep_M12B_propep	47..161	CDD:460254	27/122 (22%)
		ZnMc	209..438	CDD:469599	80/255 (31%)
		Disintegrin	445..523	CDD:459709	26/84 (31%)